울릉도 섬더덕 추출물의 급여가 제2형 당뇨동물의 지질대사 개선에 미치는 영향 = Effect of the supplementation of Coconopsis lanceolata extract on lipid metabolism amelioration in type 2 diabetes mouse model induced by high fat diet

다국어 초록 (Multilingual Abstract)

The present study was designed to investigate the antihyperlipidemic effect of Coconopsis lanceolata extract in C57BL/6J mice. The mice were divided into four groups: normal diet group (ND), high fat diet group (HFD), positive control group with 0.05% metformin (PC), Coconopsis lanceolata extract group (UCL). After 5 weeks of feeding, average body weight of the UCL group mice was slightly decreased, while that of the HFD group significantly increased) Also, liver and adipose tissue weights in the UCL group significantly increased. The levels of trigliceride (TG) and total in the plasma of UCL-supplemented group were significantly lower than those of high fat diet group. On the other hand, HDL-cholesterol level was increased. Expression level of proteins related with adipogenesis such as SREBP-1c, ACC, and FAS in the liver of the UCL group mice was much lower comparing with the HFD group mice. In conclusion, the results showed that the Coconopsis lanceolata extract possesses significant antihyperlipidemic effects in C57BL/6J mice.

참고문헌 (Reference)

1 김현주, "에너지균형에 미치는 흰지방조직 내 혈관의 역할" 대한소아내분비학회 16 (16): 139-156, 2011

2 박성혜, "생식 제품의 섭취가 건강한 성인여성의 영양섭취상태, 식행동, 혈청지질농도 및 건강지표에 미치는 영향" 한국영양학회 36 (36): 49-63, 2003

3 양은주, "보리순이 고지방을 급여한 마우스의 지질 함량과 간조직의 지질대사 관련 효소활성에 미치는 영향" 한국영양학회 42 (42): 14-22, 2009

4 엄민영, "느릅나무 뿌리 에탄올 추출물이 고지방 식이를 섭취한 마우스의 지질대사에 미치는 영향" 한국식품영양학회 26 (26): 8-14, 2013

5 박성진, "고지방식이를 섭취한 흰쥐에서 숙성더덕추출물이 혈청지질농도개선 효과에 미치는 영향" 동아시아식생활학회 22 (22): 17-24, 2012

6 Ministry of Health and Welfare, "Year book of health and welfare statistics" 51-77, 2005

7 Shin SW, "Study on antimicrobial and antioxidant effects of cosmetic including Codonopsis lanceolata" Wonkang University 2011

8 Foretz M, "Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes" 96 : 12737-12742, 1999

9 Cohen JC, "Serum triglyceride reponses to fatty meals: effects of meal far content" 47 : 825-, 1988

10 Choi MS, "Plant regeneration and saponin contents in Condonopsis lanceolata L" 7 : 275-281, 1990

11 Aggoun Y, "Obesity, metabolic syndrome, and cardiovascular disease" 61 : 653-659, 2007

12 Albu J, "Obesity solutions: report of a meeting" 55 : 150-156, 1997

13 Lee YE, "Natural food material" Kyomunsa Publishers Inc 150-151, 2003

14 Susan EC, "High fat diets varying in ratio of polyunsaturated to saturated fatty acid and linoleic to linolenic acid: A comparison of rat neural and red cell membrane phospholipids" 116 : 718-, 1986

15 조현국, "Extracts of Codonopsis lanceolataDecrease CCl4-Induced Hepatotoxicity on High Fat Diet in Rats" 대한의생명과학회 10 (10): 447-452, 2004

16 Chen W, "Expression of peroxisome proliferatoractivated receptor and CCAAT/enhancer binding protein transcription factors in cultured human sebocytes" 121 : 441-, 2003

17 Allain CC, "Enzymatic determination of total serum cholesterol" 2 : 470-475, 1974

18 Oh HC, "Effect of various partition extracts of Radix Codonopsis lanceolata on the melanogenesis" Wonkang University 2003

19 Han EG, "Effect of Codonopsis lanceolata water extract on the activities of antioxidative enzymes in carbon tetrachloride treated rats" 26 : 1181-1186, 1997

20 Suh JS, "Effect of Codonopsis lanceolata radix water extract on immunocytes" 9 : 379-384, 1996

21 Han EG, "Effect of Codonopsis lancedata water extract on the level of lipid in rats fed high fat diet" 27 : 940-944, 1998

22 Han EG, "Effect of Codonopsis lancedata water extract on the activities of antioxidative enzyme in carbon tetrachloride treated rats" 26 : 1181-1186, 1997

23 Anderson JW, "Dietary fiber and coronary heart disease" 29 : 95-147, 1990

24 Daan K, "Dietary fats: Long-term implications for health" 50 : 49-, 1992

25 Kritchevsky D, "Diet and atherosclerosis" 84 : 615-632, 1976

26 Warnick GR, "Dextran sulfate-Mg2+ precipitation procedure for quantitation of high-densitylipoprotein cholesterol" 28 : 1385-1397, 1982

27 Hong JS, "Composition of organic acid, fatty acid in Pleurotus ostreatus, Lentinus edodes & Agaricus bisporus" 20 : 100-106, 1998

28 Lee GD, "Antioxidative and nitrite-scavenging activities of edible mushrooms" 29 : 432-436, 1997

29 Seo JB, "Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor gamma expression" 24 : 3430-, 2004