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      양파와 알로에 복합물이 혈소판 응집에 미치는 영향 = Anti-platelet Effects of Mixtures of Onion and Aloe Extract

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      https://www.riss.kr/link?id=A100314209

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      다국어 초록 (Multilingual Abstract)

      In this study, we investigated whether the mixtures of onion water extract and aloe ethanol extracts have anti- platelet activities. The mixtures inhibited collagen- and thrombin-induced rat platelet aggregation in vitro. Additionally, the oral admini...

      In this study, we investigated whether the mixtures of onion water extract and aloe ethanol extracts have anti- platelet activities. The mixtures inhibited collagen- and thrombin-induced rat platelet aggregation in vitro. Additionally, the oral administration of the mixtures inhibited platelet aggregation induced by collagen ex vivo but not prolonged mouse tail vein bleeding time in vivo. These results suggest that the combination of onion and aloe extracts has a potential to be a preventive agent against platelet-mediated disorders.

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      목차 (Table of Contents)

      • 실험방법
      • 실험결과
      • 고찰 및 결론
      • 감사의 말씀
      • References
      • 실험방법
      • 실험결과
      • 고찰 및 결론
      • 감사의 말씀
      • References
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      참고문헌 (Reference)

      1 Farndale, R. W., "The role of collagen in thrombosis and hemostasis" 2 : 561-, 2004

      2 Cazenave, J. P., "Preparation of washed platelet suspensions from human and rodent blood" 272 : 13-, 2004

      3 Mustard, J. F., "Preparation of suspensions of washed platelets from humans" 22 : 193-, 1972

      4 Nieswandt, B., "Platelets in atherothrombosis:lessons from mouse models" 3 : 1725-, 2005

      5 Lefkovits, J., "Platelet glycoprotein IIb/IIIa receptors in cardiovascular medicine" 332 : 1553-, 1995

      6 Couch, J. R., "Platelet aggregation, stroke, and transient ischemic attack in middle-aged and elderly patients" 26 : 888-, 1976

      7 Davi, G., "Platelet activation and atherothrombosis" 357 : 2482-, 2007

      8 Hyun, S. W., "Onion (Allium cepa) extract attenuates brain edema" ELSEVIER SCIENCE INC 29 : 244-249, 2013

      9 Murugappan, S., "Molecular mechanism and functional implications of thrombin-mediated tyrosine phosphorylation of PKC delta in platelets" 106 : 550-, 2005

      10 Park, S., "Methanolic extract of onion (Allium cepa) attenuates ischemia/hypoxia-induced apoptosis in cardiomyocytes via antioxidant effect" DR DIETRICH STEINKOPFF VERLAG 48 : 235-242, 2009

      1 Farndale, R. W., "The role of collagen in thrombosis and hemostasis" 2 : 561-, 2004

      2 Cazenave, J. P., "Preparation of washed platelet suspensions from human and rodent blood" 272 : 13-, 2004

      3 Mustard, J. F., "Preparation of suspensions of washed platelets from humans" 22 : 193-, 1972

      4 Nieswandt, B., "Platelets in atherothrombosis:lessons from mouse models" 3 : 1725-, 2005

      5 Lefkovits, J., "Platelet glycoprotein IIb/IIIa receptors in cardiovascular medicine" 332 : 1553-, 1995

      6 Couch, J. R., "Platelet aggregation, stroke, and transient ischemic attack in middle-aged and elderly patients" 26 : 888-, 1976

      7 Davi, G., "Platelet activation and atherothrombosis" 357 : 2482-, 2007

      8 Hyun, S. W., "Onion (Allium cepa) extract attenuates brain edema" ELSEVIER SCIENCE INC 29 : 244-249, 2013

      9 Murugappan, S., "Molecular mechanism and functional implications of thrombin-mediated tyrosine phosphorylation of PKC delta in platelets" 106 : 550-, 2005

      10 Park, S., "Methanolic extract of onion (Allium cepa) attenuates ischemia/hypoxia-induced apoptosis in cardiomyocytes via antioxidant effect" DR DIETRICH STEINKOPFF VERLAG 48 : 235-242, 2009

      11 Jennings, L. K., "Mechanisms of platelet activation: need for new strategies to protect against platelet-mediated atherothrombosis" 102 : 248-, 2009

      12 Asamenew, G., "In vitro antimicrobial and antioxidant activities of anthrone and chromone from the latex of Aloe harlana Reynolds" 25 : 1756-, 2011

      13 Kuijpers, M. J., "Factor XII regulates the pathological process of thrombus formation on ruptured plaques" 34 : 1674-, 2014

      14 Singhal, A., "Colon-targeted quercetin delivery using natural polymer to enhance its bioavailability" 3 : 35-, 2011

      15 Chen, Z. M., "COMMIT (ClOpidogrel and Metoprolol in Myocardial Infarction Trial) collaborative group., Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial infarction: randomized placebo-controlled trial" 366 : 1607-, 2005

      16 Navarro-Nunez, L., "Apigenin inhibits platelet adhesion and thrombus formation and synergizes with aspirin in the suppression of the arachidonic acid pathway" 56 : 2970-, 2008

      17 El-Shemy, H. A., "Antitumor properties and modulation of antioxidant enzymes' activity by Aloe vera leaf active principles isolated via supercritical carbon dioxide extraction" 17 : 129-, 2010

      18 Chung, M. I., "Antiplatelet effects and vasorelaxing action of some constituents of Formosan plants" 56 : 929-, 1993

      19 Yu, H. Y., "Anti-platelet effects of yuzu extract and its component" PERGAMON-ELSEVIER SCIENCE LTD 49 (49): 3018-3024, 2011

      20 Yamada, K., "An onion variety has natural antithrombotic effect as assessed by thrombosis/thrombolysis models in rodents" 114 : 213-, 2004

      21 Kim, J. S., "A randomized crossover comparative study of aspirin, cilostazol and clopidogrel in normal controls: analysis with quantitative bleeding time and platelet aggregation test" CHURCHILL LIVINGSTONE 11 (11): 600-602, 2004

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2027 평가예정 재인증평가 신청대상 (재인증)
      2021-01-01 평가 등재학술지 유지 (재인증) KCI등재
      2018-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2015-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2011-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2009-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2007-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2004-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2003-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2002-01-01 평가 등재후보학술지 유지 (등재후보1차) KCI등재후보
      1999-07-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.2 0.2 0.22
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.23 0.18 0.403 0.02
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