Strength training protects against prostate injury in alcoholic rats

다국어 초록 (Multilingual Abstract)

Alcoholic injury can alter the hormonal signaling pathway and lead to glucose and lipid metabolism disorders. In this study, we investigated whether the strength training could exert protective effects against the alterations caused by ethanol consumption on prostatic metabolism. A UChB, ethanol‐preferring rats were used in this study. Strength training was conducted for 3 days per week for 13 weeks, rats performed jumps in water carrying a weight load strapped to their chests as part of a strength training protocol. The reduced alcohol consumption by strength training was accompanied by increased glucose, serum lipid profile, total protein levels, and reduced hormonal levels. The results of protein expression of prostatic tissues in the ethanol‐ and strength training‐treated groups indicated that “steroidal hormone receptors,” “fatty acid translocation,” and “cell regulation” were significantly different between ethanol‐ and strength training‐treated groups. Taken together, these findings show that strength training effectively ameliorated prostatic injuries in alcoholic rats at least partially by acting on lipids receptors and steroidal hormone receptors pathway, suggesting the strength training as a potential novel therapeutic strategy for treating prostate injuries caused by ethanol.

Long‐term strength training reduces prostatic changes promoted by chronic alcohol consumption by regulating steroid hormones, prostatic steroid receptors and reducing cell proliferation;
Long‐term strength training practice reduces voluntary alcohol consumption;
Levels of plasma corticosterone and glucocorticoids receptors are higher in strength‐trained animals;
Levels of total protein and plasma lipids are lower in animals consuming ethanol;
Levels of prostatic lipids and cell apoptosis are induced by strength training.





Long‐term strength training reduces prostatic changes promoted by chronic alcohol consumption by regulating steroid hormones, prostatic steroid receptors and reducing cell proliferation;
Long‐term strength training practice reduces voluntary alcohol consumption;
Levels of plasma corticosterone and glucocorticoids receptors are higher in strength‐trained animals;
Levels of total protein and plasma lipids are lower in animals consuming ethanol;
Levels of prostatic lipids and cell apoptosis are induced by strength training.