호흡기 바이러스의 연령별, 성별, 계절별에 따른 유병률 변화: 단일기관에서 10년 동안 호흡기 질환으로 입원한 소아 환자를 중심으로 = Prevalence of respiratory virus infection with regard to age, sex, and seasonality factors: A single center experience against children hospitalized during the 10 years

다국어 초록 (Multilingual Abstract)

Purpose: It is well known that respiratory viral infection has epidemiological characteristics, including season. This study aimed to investigate the patterns of the prevalence of common respiratory viruses during a period of 10 years with regard to age, sex, and season in Korean children.
Methods: From June 2006 to November 2016, we obtained 11,798 specimens from patients aged less than 18 years who were admitted with lower respiratory infections. Ten respiratory viruses were detected using multiplex reverse transcription-polymerase chain reaction.
Results: Of 11,798 specimens, at least 1 virus was detected in 4,845 (41.1%). Respiratory syncytial virus (RSV, 18.9%) was the most common virus detected, followed by human rhinovirus (HRV, 14.8%), adenovirus (9.5%), and human bocavirus (HBoV, 7.4%). The detection rate of HRV was higher in male subjects (male 60.0% vs. female 40.0%, P=0.004), but the other viruses had no significant differences with regard to sex. The subjects who were positive for RSV test were youngest (median, 10.5 months; interquartile range, 3.0-25.0 months), followed by human coronavirus (median, 13.0 months), HRV (median, 14 months), and parainfluenza (median, 14 months). HBoV was most commonly detected in spring (29.3%), enterovirus in summer (25.8%), HRV in fall (22.6%), and RSV in October and winter (22.6%).
Conclusion: We found that the prevalence of respiratory viruses in Korean children during a period of 10 years was associated with age, sex, and season when the infection occurred. Further nationwide data is warranted to infer clinical implication of our results.
(Allergy Asthma Respir Dis 2017;5:320-325)

참고문헌 (Reference)

1 김유경, "소아에서 발병한 human metapneumovirus와 respiratory syncytial virus에 의한 호흡기 감염의 임상 양상" 대한 소아알레르기 호흡기학회 19 (19): 12-19, 2009

2 박준수, "소아 급성 바이러스 하기도염" 대한소아과학회 52 (52): 269-276, 2009

3 정진우, "부산지역 급성 호흡기 증상으로 외래 방문한 환자의 바이러스 원인과 역학: 2007-2008년" 대한소아감염학회 17 (17): 130-136, 2010

4 Bi P, "Weather variables and Japanese encephalitis in the metropolitan area of Jinan city, China" 55 : 551-556, 2007

5 Singleton RJ, "Viral respiratory infections in hospitalized and community control children in Alaska" 82 : 1282-1290, 2010

6 Krause JC, "The role of multiplex PCR in respiratory tract infections in children" 111 : 639-645, 2014

7 Hacimustafaoglu M, "The progression of maternal RSV antibodies in the offspring" 89 : 52-53, 2004

8 Choi EH, "The association of newly identified respiratory viruses with lower respiratory tract infections in Korean children, 2000-2005" 43 : 585-592, 2006

9 Tse SM, "Sex-specific risk factors for childhood wheeze and longitudinal phenotypes of wheeze" 138 : 1561-1568, 2016

10 Meddens MJ, "Serodiagnosis of respiratory syncytial virus (RSV) infection in children as measured by detection of RSV-specific immunoglobulins G, M, and A with enzyme-linked immunosorbent assay" 28 : 152-155, 1990

11 Fisman D, "Seasonality of viral infections: mechanisms and unknowns" 18 : 946-954, 2012

12 Weigl JA, "Seasonality of respiratory syncytial virus-positive hospitalizations in children in Kiel, Germany, over a 7-year period" 30 : 186-192, 2002

13 Shaw Stewart PD, "Seasonality and selective trends in viral acute respiratory tract infections" 86 : 104-119, 2016

14 Dowell SF, "Seasonal variation in host susceptibility and cycles of certain infectious diseases" 7 : 369-374, 2001

15 Victora CG, "Risk factors for pneumonia among children in a Brazilian metropolitan area" 93 (93): 977-985, 1994

16 Xatzipsalti M, "Rhinovirus viremia in children with respiratory infections" 172 : 1037-1040, 2005

17 Khetsuriani N, "Prevalence of viral respiratory tract infections in children with asthma" 119 : 314-321, 2007

18 Jartti T, "Persistence of rhinovirus and enterovirus RNA after acute respiratory illness in children" 72 : 695-699, 2004

19 Jartti T, "Metapneumovirus and acute wheezing in children" 360 : 1393-1394, 2002

20 Hendley JO, "Mechanisms of transmission of rhinovirus infections" 10 : 243-258, 1988

21 Lowen AC, "Influenza virus transmission is dependent on relative humidity and temperature" 3 : 1470-1476, 2007

22 Williams JV, "Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children" 350 : 443-450, 2004

23 Monto AS, "Epidemiology of viral respiratory infections" 49 : 160-174, 2003

24 Blomqvist S, "Epidemiology of human rhinoviruses" University of Helsinki 2004

25 Kim MR, "Epidemiology of acute viral respiratory tract infections in Korean children" 41 : 152-158, 2000

26 Dushoff J, "Dynamical resonance can account for seasonality of influenza epidemics" 101 : 16915-16916, 2004

27 Pillet S, "Comparative evaluation of six commercialized multiplex PCR kits for the diagnosis of respiratory infections" 8 : e72174-, 2013

28 Mäkinen TM, "Cold temperature and low humidity are associated with increased occurrence of respiratory tract infections" 103 : 456-462, 2009

29 Allander T, "Cloning of a human parvovirus by molecular screening of respiratory tract samples" 102 : 12891-12896, 2005

30 Shay DK, "Bronchiolitis-associated hospitalizations among US children, 1980-1996" 282 : 1440-1446, 1999

31 van den Bergh MR, "Associations between pathogens in the upper respiratory tract of young children: interplay between viruses and bacteria" 7 : e47711-, 2012

32 Carroll ML, "Adaptive immunity to rhinoviruses: sex and age matter" 11 : 184-, 2010

33 Shaman J, "Absolute humidity and the seasonal onset of influenza in the continental United States" 8 : e1000316-, 2010

34 van den Hoogen BG, "A newly discovered human pneumovirus isolated from young children with respiratory tract disease" 7 : 719-724, 2001