Chemical Constituents from Acer mandshuricum and Their Effects on the Function of Osteoblastic MC3T3-E1 Cells

다국어 초록 (Multilingual Abstract)

A new compound, 4-methoxyl 5-hydroxymethyl benzoic 3-O-β-D-glucopyranoside (1), has been isolated from the leaves and stems of Acer mandshuricum, along with nine known compounds (2-10). Their structures were determined by a variety of spectroscopic analyses. The effect of compounds 1-10 on the function of osteoblastic MC3T3-E1 cells was examined by determining alkaline phosphatase (ALP) activity, collagen synthesis, and mineralization. Compound 1significantly increased the function of osteoblastic MC3T3-E1 cells; 5.0 μM of 1 increased ALP activity, collagen synthesis,and mineralization of MC3T3-E1 cells to 114.7, 119.5, and 108.2% (P < 0.05) of the basal value, respectively.
In addition, compounds 2-10 also potently increased the function of osteoblastic MC3T3-E1 cells.

참고문헌 (Reference)

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