호도약침(胡桃藥鍼)이 Glycerol로 유발(誘發)된 급성신부전(急性腎不全) 백서(白鼠)에 미치는 영향(影響) = Effect of Juglandis Semen Herbal Acupuncture on Rat by Glycerol-Induced Acute Renal Failure

다국어 초록 (Multilingual Abstract)

Objective: This study was undertaken to determine if Juglandis Semen herbal acupuncture(Ja) has a protective effect against glycerol-induced acute renal failure in rats. Methods: Rats were dehydrated for 24hr and then injected with 5 ml/㎏ of 50 % glycerol, one-half of dose in each hindlimb muscle. In experiments for Ja effect, rats received 0.1 ml of Ja extraction in both sides of corresponding Shenshu(BL23) of human body and non-acupuncture points(the root of tail) for 3 days after injection of glycerol. The experimental group were divided into the Normal group, the Control group, the Ja to Shenshu(BL23) group(Ja-AS), the Ja to non-acupuncture points group(Ja-AN). Results: There were significant decrease of urine volume, BUN, fractional glucose excretion, fractional phosphate excretion, total protein level in Ja-AS as compared with the control group. Conclusion: This suggests that Ja-AS could be used in prevention and treatment of acute renal failure. However, the precise mechanisms of Ja protection remain to be determined.