Effect of long term treatment of aqueous extract of Enicostemma littorale in Type 2 diabetic patients

다국어 초록 (Multilingual Abstract)

We have evaluated the effect of long term treatment of Enicostemma littorale (E. littorale) in type 2
diabetic patients taking pills of aqueous extract of E. littorale regularly as a complimentary medicine
for at least 9 months. The effects of E. littorale on glycemic control, lipid profile, cardiac function
and DNA damage in these patients were compared with those who had not been regular in
taking E. littorale but regular in taking other conventional anti-diabetics. Our data suggest that, E.
littorale can maintain normal blood glucose, serum insulin, serum triglycerides levels of type 2
diabetic patients if taken regularly. E. littorale also improves insulin sensitivity, and normalize
disturbed lipogram and elevated creatinine levels, thereby produces beneficial effect in
preventing cardiovascular complications and may preserve the kidney function. The finding that
E. littorale also prevents DNA damage suggest a long term effect in diabetic patients. E. littorale
thus can be considered as safe supplementary therapy for a long term and effective management
of type 2 diabetic patients.

다국어 초록 (Multilingual Abstract)

We have evaluated the effect of long term treatment of Enicostemma littorale (E. littorale) in type 2
diabetic patients taking pills of aqueous extract of E. littorale regularly as a complimentary medicine
for at least 9 months. The effects of E. littorale on glycemic control, lipid profile, cardiac function
and DNA damage in these patients were compared with those who had not been regular in
taking E. littorale but regular in taking other conventional anti-diabetics. Our data suggest that, E.
littorale can maintain normal blood glucose, serum insulin, serum triglycerides levels of type 2
diabetic patients if taken regularly. E. littorale also improves insulin sensitivity, and normalize
disturbed lipogram and elevated creatinine levels, thereby produces beneficial effect in
preventing cardiovascular complications and may preserve the kidney function. The finding that
E. littorale also prevents DNA damage suggest a long term effect in diabetic patients. E. littorale
thus can be considered as safe supplementary therapy for a long term and effective management
of type 2 diabetic patients.

참고문헌 (Reference)

1 Taskinen M, "Triglyceride is the major atherogenic lipid in NIDDM" 13 : 93-98, 1997

2 King G, "Receptors and growth promoting effects of insulin and insulin like growth factors on cells from bovine retinal capillaries and aorta" 75 : 1028-1036, 1985

3 Kolterman OG, "Receptor defects contribute to the insulin resisitance in non-insulin dependent diabetes mellitus" 68 : 957-969, 1981

4 Rasch R, "Prevention of diabetic glomerulopathy in streptozotoxin-diabetic rates by insulin treatment. Kidney size and glomerular volume" 16 : 125-128, 1979

5 Retnam KR, "Preliminary phyochemical screening of three medcinal plants of tirunelveli hills" 22 : 677-681, 1988

6 Reichard P, "Nephropathy is delayed by intensified insulin treatment in patiendts with insulin dependent diabetes mellitus and retinopathy" 226 : 81-87, 1989

7 Gupta SS, "Experimental studies on pituitary-diabetes Part I, Inhibitory effect of a few Ayurvedic antidiabetic remedies on pituitary extract induced hyperglycemia in albino rats" 50 : 73-81, 1962

8 Regan TJ, "Evidence for cardiomyopathy in familial diabetes mellitus" 60 : 885-899, 1977

9 Eisenbarth GS, "Etiology and pathogenesis of diabetes mellitus. in: principles and Practice of Endocrinology and Metabolism" JB Lippincott 1074-1098, 1990

10 Upadhyay UM, "Efficacy of Enicostemma littorale in type 2 diabetic patients" 18 : 233-235, 2004

11 Defronzo RA, "Effect of insulin peripheral and splanchinc glucose metabolism in non - insulin dependent (type-2) diabetes mellitus" 76 : 149-155, 1985

12 Murali B, "Effect of chronic treatment with Enicostemma littorale in non-insulin dependent diabetic (NIDDM) rats" 81 : 199-204, 2002

13 Hansesn KF, "Diabetic control and microvascular complications. The near normoglyceia experience" 29 : 677-684, 1986

14 James RW, "Diabetes and other coronary heart disease risk equivalents" 12 : 425-431, 2001

15 Vishwakarma SL, "Comparatie antidiabetic actiiy of different fractions of Enicostemma littorale blume in streptoxotocine induced NIDDM rats" 3 : 196-204, 2003

16 Craig JW, "Clinical implications of the new diabetes classification" 68 : 122-123, 1980

17 Desai PD, "Chemical investigation of some Indian Medicinal Plants: Part II" 4 : 457-459, 1966

18 Rai J, "Chemical investigation of Enicotemma littorale Blume" 35 : 148-149, 1966

19 Natarajan PN, "Chemical investigation of Enicotemma littorale" 22 : 42-46, 1972

20 Chaudhuri RK, "Chemical constituents of gentianaceae XVIII Structure of Enicoflavine Monoterpene alkaloids from Enicostemma hyssopifolium" 3 : 127-128, 1975

21 Ghosal S, "Chemical constituents of Gentianacceae IX: natural occurrence of Erythrocentaurin in Enicostemma hissopifolium and Swertia lawii" 63 : 944-945, 1974

22 Hayden JM, "Cardiovascular disease in diabetes mellitus type 2: a potential role for noel cardiovascular risk factors" 11 : 519-528, 2000

23 Macmohan S, "Blood pressure stroke and coronary heart disease" 335 : 765-774, 1990

24 Kalseen GA, "Adaptation of the coronary circulation to primary myocardial disease" 3 : 161-168, 1973

25 Vishwakarma SL, "A sensitive HPTLC method for estimation of swertiamarin in Enicostemma littorale bume swetia chirata (wall) Clarke, and formulations containing Enicostemma littorale" 17 : 128-132, 2004

26 Vishwakaarma SL, "A rapid method for the isolation of swertiamarin from Enicostemma littorale" 42 : 400-403, 2004