제비콩 추출물이 고지방 식이 급여에 의한 흰쥐의 혈청 지질 함량에 미치는 영향 = Effects of Jebikong (Dolichos lablab) Extract on Serum Lipid Metabolism in Rats Fed a High Fat Diet

국문 초록 (Abstract)

제비콩 추출물이 고지방 및 콜레스테롤 식이 급여에 따른 흰쥐이 혈청 지질 농도에 미치는 영향에 대하여 조사하였다. 식이섭취량과 체중 증가량은 제비콩 추출물과 고지방식이군을 병합급여한 군이 고지방식이군에 비하여 약간 감소하였으나 유의한 차이는 없었다. 혈청 중 중성지질과 총콜레스테롤 농도는 제비콩 추출물과 고지방식이 병합급여군이 고지방 단독 급여군에 비하여 낮게 나타났다. HDL-콜레스테롤 농도는 제비콩 추출물과 고지방식이 병합 급여군이 고지방 식이군에 비하여 증가하였고, LDL-콜레스테롤 농도와 동맥경화지수는 감소하여 혈청 중의 지질개선에 어느 정도 효과가 있는 것으로 나타났다. 이상의 결과에서 고지방식이에 제비콩 추출물의 섭취는 혈청 중 총콜레스테롤 상승 억제, HDL-콜레스테롤 증가, LDL-콜레스테롤 감소의 결과를 가져와 지질 개선에 어느 정도 효과가 있음을 확인하였다.

다국어 초록 (Multilingual Abstract)

This study investigated the effect of Dolichos lablab extract on the lipid metabolism of rats fed a high fat and cholesterol diet. S-D male rats (n=48) were given 40, 400, or 4000 mg/kg of Dolichos lablab extract and fed a high fat and high cholesterol diet for four weeks (DL-HFC group). As a result, serum levels of total lipids, total cholesterol, and triglycerides were higher in the high fat and high cholesterol group (HFC-group) than the control, and significant differences were observed between the control and the DL-HFC (40, 400, 4000 mg/kg) group. The fat absorption rate increased with a high fat diet feeding, but was higher in the DL-HFC (40, 400, 4000 mg/kg) group.

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