Preparation and Applications of Poly(DL-lactide-co-glycolide) nanoparticles = Poly(DL-lactide-co-glycolide) 나노 입자의 제조 및 그 응용

다국어 초록 (Multilingual Abstract)

Poly(DL-lactide-co-glycolide) (PLGA) has two types ; one is PLGA (RG 502) and the other is PLGA (RG 502H). The surfactant-free nanoparticles of PLGA were prepared by dialysis method without surfactant and physicochemical properties such as particle size and drug contents were investigated against used initial solvent. Used initial solvents are dimethylacetamide (DMAc), dimethylformamide (DMF), dimethylsulfoxide (DMSO), and acetone, respectively. PLGA(RG 502) nanoparticles had spherical shapes from the results of scanning electron microscopy(SEM) and transmission electron microscopy(TEM) observations. And it was investigated on the surface of nanoparticles through the analysis of X-ray powder diffraction. Also, PLGA(RG 502H) nanoparticles have been observed SEM, TEM, and X-ray powder diffraction. From these results, we have studied release behavior of norfloxacin (NFX)-loaded PLGA(RG 502) and PLGA(RG 502H).