The Association between Persistent Hypertriglyceridemia and the Risk of Diabetes Development: The Kangbuk Samsung Health Study

다국어 초록 (Multilingual Abstract)

Background: Hypertriglyceridemia is known to have an association with increased risks of insulin resistance and diabetes. The aimof this study was to investigate the risk of diabetes mellitus, according to changes in the concentrations of triglycerides, over time.
Methods: A total of 15,932 non-diabetic participants (mean age 43.2 years, 68% men) who attended five consecutive annual healthcheck-ups at Kangbuk Samsung Hospital, between January 2010 and December 2014, were recruited. Participants were classifiedaccording to their triglyceride concentrations; normal (<150 mg/dL) and abnormal (≥150 mg/dL). According to the triglyceridelevels in 2010 and 2012, subjects were divided into four groups: normal-normal, normal-abnormal, abnormal-normal, and abnormalabnormal.
The risk for incident diabetes was assessed in 2014.
Results: Among the total subjects, 67.5% belonged to the normal-normal group, 8.6% to the normal-abnormal group, 9.4% to theabnormal-normal group, and 14.5% to the abnormal-abnormal group. A total of 234 subjects (1.5%) were newly diagnosed with diabetes,between 2010 and 2014. Over 4 years, 1%, 1.5%, 2.1%, and 3.0% of the subjects developed diabetes in the normal-normal,normal-abnormal, abnormal-normal, and abnormal-abnormal groups, respectively. When the risk for incident diabetes was analyzedin the groups, after adjusting the confounding variables, a 1.58-fold increase in the risk of diabetes (95% confidence interval [CI],1.10 to 2.26) was observed in the participants with persistent hypertriglyceridemia (abnormal-abnormal group). This was attenuatedby further adjustments for body mass index (BMI) (hazard ratio, 1.25; 95% CI, 0.86 to 1.80).
Conclusion: In this large study population, persistent hypertriglyceridemia, over a period of 2 years, was significantly associatedwith the risk of incident diabetes, which was attenuated after adjustment for BMI.

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