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KCITumor-associated macrophages (TAMs) exhibit the M2 phenotype and serve as critical tumor-promotingimmune cells in the tumor microenvironment. As TAMs are an important target, we examined the effectof gold nanoparticles (AuNPs) with radiotherapy (RT) o...
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RISS 인기검색어
Enhancement of antitumor effect of radiotherapy via combination with Au@SiO2 nanoparticles targeted to tumor-associated macrophages
한글로보기https://www.riss.kr/link?id=A106838801
-
저자
Mi Sun Kim (Yonsei University College of Medicine) ; Jae Sang Lee (Yonsei University) ; Jung-Eun Kim (Yonsei University) ; Jae-Won Kim (Yonsei University) ; 복서연 (Yonsei University) ; KiChangKeum (Yonsei University) ; Won-Gun Koh (Yonsei University) ; Woong Sub Koom (Yonsei University)
- 발행기관
- 학술지명
- 권호사항
-
발행연도
2020
-
작성언어
English
- 주제어
-
등재정보
KCI등재,SCOPUS,SCIE
-
자료형태
학술저널
- 발행기관 URL
-
수록면
349-357(9쪽)
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KCI 피인용횟수
0
- DOI식별코드
- 제공처
-
0
상세조회 -
0
다운로드
부가정보
다국어 초록 (Multilingual Abstract)
Tumor-associated macrophages (TAMs) exhibit the M2 phenotype and serve as critical tumor-promotingimmune cells in the tumor microenvironment. As TAMs are an important target, we examined the effectof gold nanoparticles (AuNPs) with radiotherapy (RT) on M2 TAMs in tumors. We synthesized CD163antibody-conjugated, silica-coated AuNPs (CD163-GNPs) that were specifically recognized by M2 TAMs.
Bone marrow-derived macrophages and Raw 264.7 macrophages were polarized into M1 and M2phenotypes. The effect of CD163-GNPs combined with RT was evaluated in a CT26 syngeneic mousemodel (BALB/c mice). Immunostaining,flow cytometry, microscopic analyses, enzyme-linkedimmunosorbent assay, quantitative real-time polymerase chain reaction (qRT-PCR), and tumor growthdelay assay were performed following irradiation combined with CD163-GNP treatment. We observedselective phagocytosis of CD163-GNPs by Raw 264.7 macrophages following M1/M2 polarization.
Immunostaining analyses revealed higher numbers of CD163-GNPs taken up by M2 macrophages thanM0 or M1 type. CD163-GNPs combined with RT significantly reduced tumor growth in the CT26syngeneic mouse model. Macrophages subjected to the combination treatment showed increasedexpression of M1 markers. The depletion of M2 TAMs in tumors upon combination treatment withCD163-GNPs enhances the efficiency of RT.
Bone marrow-derived macrophages and Raw 264.7 macrophages were polarized into M1 and M2phenotypes. The effect of CD163-GNPs combined with RT was evaluated in a CT26 syngeneic mousemodel (BALB/c mice). Immunostaining,flow cytometry, microscopic analyses, enzyme-linkedimmunosorbent assay, quantitative real-time polymerase chain reaction (qRT-PCR), and tumor growthdelay assay were performed following irradiation combined with CD163-GNP treatment. We observedselective phagocytosis of CD163-GNPs by Raw 264.7 macrophages following M1/M2 polarization.
Immunostaining analyses revealed higher numbers of CD163-GNPs taken up by M2 macrophages thanM0 or M1 type. CD163-GNPs combined with RT significantly reduced tumor growth in the CT26syngeneic mouse model. Macrophages subjected to the combination treatment showed increasedexpression of M1 markers. The depletion of M2 TAMs in tumors upon combination treatment withCD163-GNPs enhances the efficiency of RT.
Tumor-associated macrophages (TAMs) exhibit the M2 phenotype and serve as critical tumor-promotingimmune cells in the tumor microenvironment. As TAMs are an important target, we examined the effectof gold nanoparticles (AuNPs) with radiotherapy (RT) on M2 TAMs in tumors. We synthesized CD163antibody-conjugated, silica-coated AuNPs (CD163-GNPs) that were specifically recognized by M2 TAMs.
Bone marrow-derived macrophages and Raw 264.7 macrophages were polarized into M1 and M2phenotypes. The effect of CD163-GNPs combined with RT was evaluated in a CT26 syngeneic mousemodel (BALB/c mice). Immunostaining,flow cytometry, microscopic analyses, enzyme-linkedimmunosorbent assay, quantitative real-time polymerase chain reaction (qRT-PCR), and tumor growthdelay assay were performed following irradiation combined with CD163-GNP treatment. We observedselective phagocytosis of CD163-GNPs by Raw 264.7 macrophages following M1/M2 polarization.
Immunostaining analyses revealed higher numbers of CD163-GNPs taken up by M2 macrophages thanM0 or M1 type. CD163-GNPs combined with RT significantly reduced tumor growth in the CT26syngeneic mouse model. Macrophages subjected to the combination treatment showed increasedexpression of M1 markers. The depletion of M2 TAMs in tumors upon combination treatment withCD163-GNPs enhances the efficiency of RT.
참고문헌 (Reference)
1 Y. Wang, 9 : 185-, 2018
2 L. Su, 11 : 4191-, 2015
3 A. Teresa Pinto, 6 : 18765-, 2016
4 X. Miao, 18 : 2017
5 J. W. Pollard, 4 : 71-, 2004
6 A. P. Cardoso, 33 : 2123-, 2014
7 A. Mantovani, 25 : 677-, 2004
8 A. P. Cardoso, 15 : 456-, 2015
9 S. Vinogradov, 9 : 695-, 2014
10 S. H. Cho, 54 : 4889-, 2009
1 Y. Wang, 9 : 185-, 2018
2 L. Su, 11 : 4191-, 2015
3 A. Teresa Pinto, 6 : 18765-, 2016
4 X. Miao, 18 : 2017
5 J. W. Pollard, 4 : 71-, 2004
6 A. P. Cardoso, 33 : 2123-, 2014
7 A. Mantovani, 25 : 677-, 2004
8 A. P. Cardoso, 15 : 456-, 2015
9 S. Vinogradov, 9 : 695-, 2014
10 S. H. Cho, 54 : 4889-, 2009
11 J. Xu, 73 : 2782-, 2013
12 J. W. Yoo, 16 : 2298-, 2010
13 A. Sica, 42 : 717-, 2006
14 P. Allavena, 167 : 195-, 2012
15 L. Yang, 10 : 58-, 2017
16 N. G. Bastus, 27 : 11098-, 2011
17 G. Solinas, 86 : 1065-, 2009
18 D. I. Gabrilovich, 12 : 253-, 2012
19 B. Ruffell, 33 : 119-, 2012
20 C. S. Chiang, 2 : 89-, 2012
21 A. Weigert, 19 : 95-, 2008
22 F. O. Martinez, 27 : 451-, 2009
23 T. Lu, 121 : 4015-, 2011
24 X. Bao, 96 : 2016
25 R. Pal, 38 : 332-, 2016
26 D. Hong, 7 : 2015
27 K. Binnemars-Postma, 18 : 2017
28 A. P. Cardoso, 23 : 157-, 2015
29 A. Sica, 72 : 4111-, 2015
30 F. Y. McWhorter, 72 : 1303-, 2015
31 A. Sica, 122 : 787-, 2012
32 J. Veeraraghavan, 286 : 21588-, 2011
33 F. Kratochvill, 12 : 1902-, 2015
34 S. Sathishkumar, 1 : 141-, 2002
35 A. K. Fuchs, 85 : 78-, 2016
36 A. Laskar, 441 : 737-, 2013
37 김미선, "Gold nanoparticles enhance anti-tumor effect of radiotherapy to hypoxic tumor" 대한방사선종양학회 34 (34): 230-238, 2016
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분석정보
인용정보 인용지수 설명보기
학술지 이력
| 연월일 | 이력구분 | 이력상세 | 등재구분 |
|---|---|---|---|
| 2023 | 평가예정 | 해외DB학술지평가 신청대상 (해외등재 학술지 평가) | |
| 2020-01-01 | 평가 | 등재학술지 유지 (해외등재 학술지 평가) | |
| 2011-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
| 2009-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
| 2007-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
| 2004-01-01 | 평가 | 등재학술지 선정 (등재후보2차) | |
| 2003-01-01 | 평가 | 등재후보 1차 PASS (등재후보1차) |  |
| 2001-07-01 | 평가 | 등재후보학술지 선정 (신규평가) | |
학술지 인용정보
| 기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
|---|---|---|---|
| 2016 | 3.4 | 0.75 | 2.84 |
| KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
| 2.39 | 2.24 | 0.397 | 0.56 |
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