UTE sequences with a minimal nominal TE of 8 µs have shown promise for direct imaging of myelin protons (T2, < 1 ms). However, there is still debate about the efficiency of 2D slice‐selective UTE sequences in exciting myelin protons becaus...
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https://www.riss.kr/link?id=O119773435
2018년
-
0740-3194
1522-2594
SCI;SCIE;SCOPUS
학술저널
538-547 [※수록면이 p5 이하이면, Review, Columns, Editor's Note, Abstract 등일 경우가 있습니다.]
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
UTE sequences with a minimal nominal TE of 8 µs have shown promise for direct imaging of myelin protons (T2, < 1 ms). However, there is still debate about the efficiency of 2D slice‐selective UTE sequences in exciting myelin protons becaus...
UTE sequences with a minimal nominal TE of 8 µs have shown promise for direct imaging of myelin protons (T2, < 1 ms). However, there is still debate about the efficiency of 2D slice‐selective UTE sequences in exciting myelin protons because the half excitation pulses used in these sequences have a relatively long duration (e.g., 0.3–0.6 ms). Here, we compared UTE and inversion‐recovery (IR) UTE sequences used with either hard or half excitation pulses (durations 32 µs or 472 µs, respectively) for imaging myelin in native and deuterated ovine brain at 3T.
Freshly frozen ovine brains were dissected into ∼2 mm‐thick pure white matter and ∼3 to 8 mm‐thick cerebral hemisphere specimens, which were imaged before and/or after different immersion time in deuterium oxide.
Bicomponent
T2* analysis of UTE signals obtained with hard excitation pulses detected an ultrashort T2 component (STC) fraction (fS) of 0% to 10% in native specimens, and up to ∼86% in heavily deuterated specimens. fS values were significantly affected by the TIs used in IR‐UTE sequences with either hard or half excitation pulses in native specimens but not in heavily deuterated specimens. The STC
T2* was in the range of 150 to 400 µs in all UTE and IR‐UTE measurements obtained with either hard or half excitation pulses.
Our results further support myelin protons as the major source of the ultrashort
T2* signals seen on IR‐UTE images and demonstrate the potential of IR‐UTE sequences with half excitation pulses for directly imaging myelin using clinical scanners. Magn Reson Med 80:538–547, 2017. © 2017 International Society for Magnetic Resonance in Medicine.
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