Long-term outcome of ingenol mebutate gel in patients with actinic keratosis = Long-term outcome of ingenol mebutate gel in patients with actinic keratosis

다국어 초록 (Multilingual Abstract)

Actinic keratosis is an ultraviolet light-induced skin lesion. It is represented as ill-defined, multiple erythematous or brownish colored, scaly plaques in chronic sun exposed-areas of old people. The incidence of AK is increasing worldwide and it is accepted as the most frequent pre-malignant lesion in humans such as invasive squamous cell carcinoma. Because of these risk, there has been a need for improved medical approaches to the treatment of actinic keratosis. Ingenol mebutate gel shows a therapeutic effect by necrosis of dysplastic cells through a neutrophil-mediated immune effect. The distinctive advantage of ingenol mebutate gel is its short treatment schedule of two or three applications in consecutive days. It can lead to better adherence to therapy, especially in elderly patients who have poor compliance with long-term treatment. Compared to the frequency of using ingenol mebutate gel, there are a few study of its long-term effect. Therefore, we report a case of long-term outcome for 4 years of ingenol mebutate gel with good therapeutic and maintenance effect in patient with actinic keratosis.