Some of halopyrimidine nucleosides and nucleotides have potent medicinal properties. As part of a series of synthetic studies on uracil/5-fluoro-uracil derivatives aimed at obtaining improved antitumor agents, we wish to report the synthesis of 1-ally...
Some of halopyrimidine nucleosides and nucleotides have potent medicinal properties. As part of a series of synthetic studies on uracil/5-fluoro-uracil derivatives aimed at obtaining improved antitumor agents, we wish to report the synthesis of 1-allyl uracil, 1-(2'-butenyl) uracil, 1-(2',3'-dihydroxypropyl) uracil and 1-(2'-(2''-hydroxyethoxy)ethyl) uracil. These are to be tested for their antitumor activities and furthermore to be used as starting compounds for another derivatives.