1 Wolburg H, "Tight junctions of the blood-brain barrier: development, composition and regulation" 38 : 323-337, 2002
2 Paxinos G, "The rat brain in stereotaxic coordinates, 6th ed" Elsevier Academic Press 273-275, 2007
3 Hawkins BT, "The blood-brain barrier/neurovascular unit in health and disease" 57 : 173-185, 2005
4 Zlokovic BV, "The blood-brain barrier in health and chronic neurodegenerative disorders" 57 : 178-201, 2008
5 Hardy J, "The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics" 297 : 353-356, 2002
6 Csiszar A, "Synergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in $\beta$-amyloid generation and Alzheimer's disease" 305 : H1120-H1130, 2013
7 Pelisch N, "RAS inhibition attenuates cognitive impairment by reducing blood- brain barrier permeability in hypertensive subjects" 9 : 93-98, 2013
8 Deane R, "RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain" 9 : 907-913, 2003
9 Zhang H, "Proteolytic processing of Alzheimer's $\beta$-amyloid precursor protein" 120 (120): 9-21, 2012
10 Bell RD, "Neurovascular mechanisms and bloodbrain barrier disorder in Alzheimer's disease" 118 : 103-113, 2009
1 Wolburg H, "Tight junctions of the blood-brain barrier: development, composition and regulation" 38 : 323-337, 2002
2 Paxinos G, "The rat brain in stereotaxic coordinates, 6th ed" Elsevier Academic Press 273-275, 2007
3 Hawkins BT, "The blood-brain barrier/neurovascular unit in health and disease" 57 : 173-185, 2005
4 Zlokovic BV, "The blood-brain barrier in health and chronic neurodegenerative disorders" 57 : 178-201, 2008
5 Hardy J, "The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics" 297 : 353-356, 2002
6 Csiszar A, "Synergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in $\beta$-amyloid generation and Alzheimer's disease" 305 : H1120-H1130, 2013
7 Pelisch N, "RAS inhibition attenuates cognitive impairment by reducing blood- brain barrier permeability in hypertensive subjects" 9 : 93-98, 2013
8 Deane R, "RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain" 9 : 907-913, 2003
9 Zhang H, "Proteolytic processing of Alzheimer's $\beta$-amyloid precursor protein" 120 (120): 9-21, 2012
10 Bell RD, "Neurovascular mechanisms and bloodbrain barrier disorder in Alzheimer's disease" 118 : 103-113, 2009
11 Aksoy D, "Magnetic resonance imaging profile of blood-brain barrier injury in patients with acute intracerebral hemorrhage" 2 : e000161-, 2013
12 Schreiber S, "Interplay between age, cerebral small vessel disease, parenchymal amyloid-$\beta$, and tau pathology: longitudinal studies in hypertensive stroke-prone rats" 42 (42): S205-S215, 2014
13 Nag S, "Immunohistochemical detection of endothelial proteins" 89 : 489-501, 2003
14 Carnevale D, "Hypertension induces brain $\beta$-amyloid accumulation, cognitive impairment, and memory deterioration through activation of receptor for advanced glycation end products in brain vasculature" 60 : 188-197, 2012
15 Faraco G, "Hypertension enhances $A{\beta}$-induced neurovascular dysfunction, promotes $\beta$-secretase activity, and leads to amyloidogenic processing of APP" 36 : 241-252, 2016
16 Bueche CZ, "Hypertension drives parenchymal $\beta$-amyloid accumulation in the brain parenchyma" 1 : 124-129, 2014
17 Bhatia R, "Fresh and globular amyloid beta protein (1-42) induces rapid cellular degeneration: evidence for AbetaP channel-mediated cellular toxicity" 14 : 1233-1243, 2000
18 Tofts PS, "Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols" 10 : 223-232, 1999
19 Obermeier B, "Development, maintenance and disruption of the blood-brain barrier" 19 : 1584-1596, 2013
20 Ortuno JE, "DCE@urLAB: a dynamic contrast-enhanced MRI pharmacokinetic analysis tool for preclinical data" 14 : 316-, 2013
21 Bailey EL, "Cerebral small vessel endothelial structural changes predate hypertension in stroke-prone spontaneously hypertensive rats: a blinded, controlled immunohistochemical study of 5- to 21-week-old rats" 37 : 711-726, 2011
22 Ueno M, "Blood-brain barrier is impaired in the hippocampus of young adult spontaneously hypertensive rats" 107 : 532-538, 2004
23 Montagne A, "Blood-brain barrier breakdown in the aging human hippocampus" 85 : 296-302, 2015
24 Gentile MT, "Beta-amyloid deposition in brain is enhanced in mouse models of arterial hypertension" 30 : 222-228, 2009
25 Hofman A, "Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study" 349 : 151-154, 1997
26 Heye AK, "Assessment of blood-brain barrier disruption using dynamic contrast-enhanced MRI. A systematic review" 6 : 262-274, 2014
27 Nicolas M, "Amyloid precursor protein and neural development" 141 : 2543-2548, 2014
28 Wang W, "Amyloid precursor protein ${\alpha}$- and $\beta$-cleaved ectodomains exert opposing control of cholesterol homeostasis via SREBP2" 28 : 849-860, 2014
29 Miners JS, "Abeta-degrading enzymes in Alzheimer's disease" 18 : 240-252, 2008