구강 내 자극성 섬유종에서 EGFR 발현 양상 = Expression of EGFR in Oral Irritation Fibroma

다국어 초록 (Multilingual Abstract)

The aim of the present study was to investigate whether epidermal growth factor recetor(EGFR) are expressed in oral irritation fibroma. Irritation fibromas from 90 patients and control normal mucosa were studied by immunohistochemistry using EGFR. Immunohistochemistry demonstrated that the overlying mucosa of irritation fibroma revealed the strong positive expression in the prickle layer. And fibroblasts in the mass of irritation fibroma showed restricted positive expression. The macropages and fibroblasts located in the subepithelial area and the vessles in the mass of irritation fibroma showed strong positive expression. These suggest that EGFR expression by overlying epithelium, the autocrine and paracrine stimulation by EGFR in the fibroblasts and macrophages and angiogenesis via EGFR may be involved in the pathogenesis of oral irritation fibroma.