2000년도 이후에 진단된 중심성 폐암과 말초성 폐암의 임상적 차이 = Characteristics of Peripheral versus Central Lung Cancer Since 2000

다국어 초록 (Multilingual Abstract)

Objectives: The aim of this study was to explore the changes of bronchoscopic features according to epidemiologic change of lung cancer.
Methods: We performed a retrospective review of the clinical characteristics of 1,139 lung cancer patient who underwent bronchoscopy at Kosin University Hospital from January 2000 to December 2010.
Results: The age of patients increased significantly during the last decade (P < 0.001). The most common histological type was adenocarcinoma (38.1%), followed by squamous carcinoma (35.7%) and small cell carcinoma (15.3%). There was an increasing incidence of adenocarcinoma over the time (P < 0.001). Bronchoscopic feature were divided into two classes; central type, peripheral type. The peripheral type was predominant (62.3%). The proportion of peripheral type has been increased in process of time (49.7% vs. 63.7% vs. 73.7%; P < 0.01). Among the major histopathologic type of lung cancer, adenocarcinoma (81.3%) and unclassifiable non-small-cell lung cancer (73.4%), small cell carcinoma (56.9%) were associated with preferential occurrence of peripheral type. Squamous cell carcinoma of the lung more often arised in central type (59%). However, the proportion of peripheral squamous cell carcinoma has been increased. On the subgroup analysis, the median survival time of peripheral type with adenocarcinoma and small cell carcinoma were longer than central type (P < 0.05).
Conclusions: The age of the lung cancer patients at diagnosis was getting older. The most frequent histopathologic type was adenocarcinoma. The proportion of peripheral type lung cancer gradually increased over the time. The survival time of peripheral type lung cancer was longer than central type.

참고문헌 (Reference)

1 임정환, "전남대학교 병원에서 2000년 이후 진단된 폐암의 임상 특성" 대한결핵및호흡기학회 61 (61): 427-432, 2006

2 Strauss GM, "The epidemic of smoking-related adenocarcinoma of the lung: The role of the tobacco industry and filtered and low-tar cigarettes: PRS-01" 2 : S305-, 2007

3 Wynder EL, "The changing epidemiology of smoking and lung cancer histology" 103 : 143-148, 1995

4 Jackman DM, "Small-cell lung cancer" 366 : 1386-1396, 2005

5 Mountain CF, "Revisions in the International System for Staging Lung Cancer" 111 : 1710-1717, 1997

6 Bryd RB, "Radiographic abnormlities in carcinoma of the lung as related to histological cell type" 24 : 573-575, 1969

7 Tomashefski JF Jr, "Peripheral vs central squamous cell carcinoma of the lung. A comparison of clinical features, histopathology, and survival" 114 : 468-474, 1990

8 Lubin JH, "Patterns of lung cancer risk according to type of cigarette smoked" 33 : 569-576, 1984

9 Kim YC, "National survey of lung cancer in Korea, 2005" 6 : 67-73, 2007

10 Travis WD, "Lung cancer" 75 : 191-202, 1995

11 Ketchedjian A1, "Location as an important predictor of lymph node involvement for pulmonary adenocarcinoma" 132 : 544-548, 2006

12 Brooks DR, "Influence of Type of Cigarette on Peripheral versus Central Lung Cancer" 14 : 576-581, 2005

13 Jang TW, "Female lung cancer: Re-analysis of national survey of lung cancer in Korea, 2005" 9 : 57-63, 2010

14 Yu IT, "Dose-response relationship between cooking fumes exposures and lung cancer among Chinese nonsmoking women" 66 : 4961-4967, 2006

15 Huhti E, "Does the location of lung cancer affect its prognosis?" 64 : 460-465, 1983

16 Yang CP, "Differences in incidence rates of cancers of the respiratory tract by anatomic subsite and histologic type: an etiologic implication" 81 : 1828-1831, 1989

17 Ugur G, "Classification of fibreoptic bronchoscopic findings: analysis of 2,698 cases" 13 : 1-3, 2004

18 Thun MJ, "Cigarette smoking and changes in the histopathology of lung cancer" 89 : 1580-1586, 1997

19 Korean National Statistical Office, "Annual Report on the Cause of Death Statistics" Korea National Statistical Office 2006