Etiologic treatment and lifestyle modification = Etiologic treatment and lifestyle modification

다국어 초록 (Multilingual Abstract)

Liver cirrhosis had been considered an irreversible end-state of disease. However many experimental and clinical evidence are supporting that liver cirrhosis is dynamic. Discontinuing the causative factors and permitting enough time can reverse liver fibrosis/ cirrhosis. Anti-viral therapy for the patients with chronic hepatitis B or C has a role in improving fibrosis/ cirrhosis and clinical outcomes. Clinical evidence of reversal of cirrhosis in the alcohol-induced cirrhotic is still lacking. Histological improvements differ according to the degree of weight loss in the case of nonalcoholic fatty liver disease. However, the study of reversal of non-alcoholic fatty liver-related cirrhosis is sparse. Immunosuppressants including corticosteroid could reverse fibrosis in the patients with autoimmune hepatitis. Fibrosis in the patients with primary biliary cirrhosis could be improved by ursodeoxycholic acid. We need more concrete evidences for the reversal of cirrhosis in the patients with various end-stage liver diseases. And we should find where ‘the point of no return’ is in liver cirrhosis.