<P>How the p53 transcription factor/tumor suppressor inhibits cell invasion is poorly understood. We demonstrate that this function of p53 requires its direct interaction with p21(WAF1), a transcriptional target of p53, and that both p21 and p53...
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https://www.riss.kr/link?id=A107612625
Kim, Jongdoo ; Bae, Seunghee ; An, Sungkwan ; Park, Jong Kuk ; Kim, Eun Mi ; Hwang, Sang‐ ; Gu ; Kim, Wun‐ ; Jae ; Um, Hong‐ ; Duck
2014
-
SCI,SCIE,SCOPUS
학술저널
1062-1068(7쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P>How the p53 transcription factor/tumor suppressor inhibits cell invasion is poorly understood. We demonstrate that this function of p53 requires its direct interaction with p21(WAF1), a transcriptional target of p53, and that both p21 and p53...
<P>How the p53 transcription factor/tumor suppressor inhibits cell invasion is poorly understood. We demonstrate that this function of p53 requires its direct interaction with p21(WAF1), a transcriptional target of p53, and that both p21 and p53 bind to Slug, which promotes cell invasion. Functional studies reveal that p21 and p53 cooperate to facilitate Mdm2-dependent Slug degradation and that this p53 function is mimicked by p53(R273H), a mutant lacking trans-activating activity. These actions of p21 and p53 are induced by 관-irradiation of cells and also operate in vivo. This is the first study to elucidate a mechanism involving p53 and p21 cooperation.</P>