Ferulic acid, a compound isolated from herbs, has a big potential to be developed into a useful drug for the treatment of cardiovascular disease. Ferulic acid is effective at preventing cancer induced and reducing oxidative stress. but its pharmacokin...
Ferulic acid, a compound isolated from herbs, has a big potential to be developed into a useful drug for the treatment of cardiovascular disease. Ferulic acid is effective at preventing cancer induced and reducing oxidative stress. but its pharmacokinetics and hepatic uptake have almost not been reported. Thus present study was to investigate the pharmacokinetics of ferulic acid after i.v administration, and to analyze in vivo hepatic uptake of ferulic acid. We developed a convenient HPLC methods using UV/VIS detector to assay ferulic acid in the biological fluids. Plasma concentration-time profiles of ferulic acid were determined after i.v. administration at a dose of 2 mg/kg and 10 mg/kg, respectively. Moreover, tissue concentration and the excreted amount into bile or urine were determined. Ferulic acid were rapidly disappeared from the blood circulation by 15 min after its i.v. bolus injection, followed by a slow disappearance by 1 hr. The half-lives at the distributive phase (t1/2α) and post-distributive phase (t1/2β) were 1.1-1.4 min and 5-7 min, respectively. Ferulic acid was rapidly eliminated during 30 min in the bile and 12 hr in the urine. Of the various tissues tested, ferulic acid was mainly distributed in the liver, kidney and L.intestine after i.v. administration. The plasma and liver concentration of ferulic acid were determined after i.v. bolus administration at a dose of 10 mg/kg in rats and then the hepatic uptake clearance (CLuptake,in vivo) was calculated from the slope of linear range over 3 min. The hepatic uptake clearance of ferulic acid was 0.0862 ml/min/g liver.