Allelic Variation and Phylogenetic Analysis of SLA-3 between Korean Native Pigs and Other Pig Breeds

다국어 초록 (Multilingual Abstract)

Understanding the MHC polymorphisms within a population is important in terms of the immunological and genetic viewpoints. There has been little report on allelic variation of SLA genes for Korean native pigs except for our previous study on SLA-2. To characterize a MHC class I gene, SLA-3, of Korean native pigs, we cloned and analyzed the sequences of SLA-3 alleles from Korean native pigs. We found two new SLA-3 alleles from five Korean native pigs. The average SLA-3 heterozygosity level was 40%, indicating that the genetic diversity of the Korean native pig was significantly reduced and the allelic complexity is also low. To evaluate the genetic relationship of SLA-3 between Korean native pigs and other pig breeds, a phylogenetic analysis was performed. SLA-3*kn01 was clustered with SLA-3*05sw01 and SLA-3*kn02 with SLA-3*0302. The new SLA-3 alleles of Korean native pigs presented here will be useful as the first reference sequences of the SLA-3 gene from any Asian pig breed.

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