Relationship between the Polymorphism of Cytochrome P-450 2D6 and Theclinical Outcomes of Paroxetine in Korean Patients with Depressive Disorders

다국어 초록 (Multilingual Abstract)

The polymorphism of cytochrome P-450 2D6 (CYP2D6) is responsible for the metabolism of psychotropics, including antidepressants such as paroxetine. In order to maximize the clinical effects and minimize the adverse effects of antidepressants, it is important to analyze the polymorphic alleles of the CYP gene. The authors investigated the relationships between the polymorphic alleles of cytochrome P-450 2D6 gene and the clinical effects and adverse effects of paroxetine in Korean patients with depressive disorders. The study included 50 subjects (26 males, 24 females) who met the DSM-IV criterion of major depressive disorder or dysthymic disorder. A blood sample was taken from the peripheral vein of each subject and PCR and RFLP analysis was done to detect the polymorphism of CYP 2D6. We compared the clinical effects and the side effects with the polymorphic alleles of CYP 2D6. Low mutation frequencies of 2 major loci of the CYP 2D6 gene were observed. There was no relationship between the polymorphic alleles of the CYP 2D6 gene and the clinical effects and adverse effects of paroxetine in Korean patients with depressive disorders. Although limited by the small number of subjects, limited number of loci studied and the non-use of an approved scale of measurement, this study nevertheless suggested that there was a low frequency of mutation in the major loci of the CYP 2D6 gene, and that no relationship existed between the polymorphic alleles and clinical outcomes in Korean patients with depressive disorders.