D-dimer level in chronic urticaria patients = D-dimer level in chronic urticaria patients

다국어 초록 (Multilingual Abstract)

Background: Chronic urticaria is a common disorder affecting 1% of population. The pathophysiology of chronic urticaria is not clearly known but the role of extrinsic coagulation pathway is thought to be suggestiverecently. D-dimer is a degradation product by fibrinolysis and activation of coagulation pathway elevates D-dimer. There are controversial studies suggesting role of D-dimer in urticaria patients. Objectives: The aim of this study is to compare D-dimer level in chronic urticaria and acute urticaria patients and evaluate association between D-dimer level and response to antihistamine in chronic urticaria and the change in response to antihistamine after normalization of D-dimer by tranexamic acid. Methods: We retrospectively reviewed patients who were diagnosed as urticaria and checked D-dimer level in department of dermatology, Samsung Medical Center, Seoul, from 2010 to 2014. Results: 716 chronic urticaria patients and 36 acute urticaria pateints were included and average D-dimer level was 0.45 and 1.49 respectively. Propertion of D-dimer elevated patient was 21.1% and 41.7% respectively. D-dimer level was significantly high in antihistamine poor responders than good to partial responders, but theproportion of D-dimer elevated patient was notsignificant. After D-dimer normalization with tranexamic acid, 42.4% of antihistamine poor responders showed better response. Conclusion: D-dimer may be a biomarker for anti- histamine resistant chronic urticaria.