염생식물 갯질경이의 Peroxynitrite 소거 활성 = Peroxynitrite-scavenging Activity of the Halophyte Limonium tetragonum

다국어 초록 (Multilingual Abstract)

Crude extracts of Limonium tetragonum and their solvent-partitioned fractions were evaluated for their potential to scavenge authentic ONOO−, and ONOO− derived from 3-morpholinosydnonimine (SIN-1). Four flavonol glycosides (1-4) were isolated by activity-guided separation. Their chemical structures were elucidated by extensive 2 D NMR experiments and by comparison with published spectral data. These compounds were also estimated for their peroxynitrite scavenging effects. The scavenging ratios of compounds 1-4 on authentic ONOO− were 56, 37, 56, and 54%, respectively, at a concentration of 1 μM. On the other hand, the inbihition ratios of compounds 1-4 against ONOO− generation from SIN-1 were 59, 39, 44, and 54% at the same concentration, respectively.

참고문헌 (Reference)

1 공창숙, "염생식물 갯질경(Limonium tetragonum의 추출물이 미치는 효과" 한국생물공학회 23 (23): 177-182, 2008

2 박희준, "어수리 어린 잎으로부터 Peroxynitrite 소거활성을 나타내는 플라보노이드 성분의 분리 및 함량분석" 한국자원식물학회 23 (23): 393-398, 2010

3 Foo LY, "The phenols and prodelphinidins of white clover flowers" 54 : 539-548, 2000

4 Fridorich L, "The biology of oxygen radicals" 201 : 875-881, 1978

5 류동영, "Study on the inhibitory effects of Korean medicinal plants and their main compounds on the 1 1-diphenyl-2-picrylhydrazyl radical" 10 (10): 544-551, 200306

6 Hamed KB, "Sea fennel (Crithmum maritimum L.) under salinity conditions: a comparison of leaf and root antioxidant responses" 53 : 185-194, 2007

7 Dreher D, "Role of oxygen free radicals in cancer development" 32 : 30-38, 1996

8 Hansen MB, "Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill" 119 : 203-210, 1989

9 Yoshimura M, "Polyphenolic compounds isolated from the leaves of Myrtus communis" 62 : 366-368, 2008

10 Virag L, "Peroxynitriteinduced cytotoxicity: mechanism and opportunities for intervention" 140 (140): 113-124, 2003

11 Kooy NW, "Peroxynitrite-mediated oxidation of dihydrorhodamine 123" 16 : 149-156, 1994

12 Klotz LO, "Peroxynitrite signaling: receptor tyrosine kinases and activation of stressresponsive pathways" 33 : 737-743, 2002

13 Chung SK, "Novel flavonol glycoside, 7-O-methyl mearnsitrin, from Sageretia theezans and its antioxidant effect" 52 : 4664-4668, 2004

14 Korda M, "Leptininduced endothelial dysfunction in obesity" 295 : 1514-1521, 2008

15 Dae-Young Lee, "Isolation of Flavonoids from the Fruits of Cornus kousa Burg.†" 한국응용생명화학회 50 (50): 144-147, 2007

16 Ksouri R, "Influence of biological, environmental and technical factorson phenolic content and antioxidant activities of Tunisian halophytes" 331 : 865-873, 2008

17 Piao MJ, "Hyperoside prevents oxidative damage induced by hydrogen peroxide in lung fibroblast cells via an antioxidant effect" ELSEVIER SCIENCE BV 1780 : 1448-1457, 2008

18 Hossein N, "Free radical scavengers from the aerial parts of Euphorbia petiolata" 64 : 187-190, 2010

19 Kong CS, "Flavonoid glycosides isolated from Salicornia herbacea inhibit matrix metalloproteinase in HT1080 cells" Elsevier BV 22 (22): 1742-1748, 2008

20 Jithesh MN, "Antioxidative response mechanisms in halophytes: their role in stress defence" 85 : 237-254, 2006

21 Blois MS, "Antioxidant determinations by the use of a stable free radical" 26 : 1199-1200, 1958

22 Ksouri R, "Antioxidant and antimicrobial activities of the edible medicinal halophyte Tamarix gallica L. and related polyphenolic constituents" 47 : 2083-2209, 2009

23 Conforti F, "Antioxidant activity of methanolic extract of Hypericum triquetrifolium Turra aerial part" 73 : 479-483, 2002

24 Yamazaki E, "Antioxidant activity of Japanese pepper (Zanthoxylum piperitum DC.) fruit" 100 : 171-177, 2007

25 Drel VR, "A peroxynitrite decomposition catalyst counteracts sensory neuropathy in streptozotocin-diabetic mice" 569 : 45-48, 2007