Systemic Review for The Effectiveness of Current Conservative Treatment in Necrotizing Pancreatitis

다국어 초록 (Multilingual Abstract)

The standard treatment of pancreatic necrosis has been surgical necrosectomy. There has been debate on whether early surgical intervention can reduced by infected pancreatic necrosis (IPN). Early emergency laparotomy and multiple organ failure remain associated with high mortality. However, reports have presented during the last 10 years of survival of severe acute pancreatitis with medical management. Large and multicenter study showed that about two thirds of patients with necrotizing pancreatitis can be treated conservatively with relatively low mortality. Patients with IPN benefit from postponding intervention and minimal invasive treatment. We reviewed 4 literatures including 2 Korean institute reseached reports concerning non-surgical, conservative treatments of necrotizing pancreatitis including IPN. Large and multicenter study showed that about two thirds of patients with necrotizing pancreatitis can be treated conservatively with relatively low mortality.

참고문헌 (Reference)

1 송주형, "감염된 중증 괴사췌장염의 내과 치료 성적" 대한소화기학회 48 (48): 337-343, 2006

2 Gurusamy KS, "UK guidelines for the managemnt of acute pancreatitis: is it time to change?" 54 : 1344-1345, 2005

3 Besseolink MG, "Timing of surgical intervention in necrotizing pancreatitis" 142 : 1194-1201, 2007

4 Besselink MG, "Timing and impact of infections in acute pancreatitis" 96 : 267-273, 2009

5 Lee JK, "The efficacy of nonsurgical treatment of infected pancreatic necrosis" LIPPINCOTT WILLIAMS & WILKINS 34 : 399-404, 2007

6 Lee JK, "The efficacy of nonsurgical treatment of infected pancreatic necrosis" LIPPINCOTT WILLIAMS & WILKINS 34 : 399-404, 2007

7 Ranson JH, "Prognostic signs and role of operative management in acute pancreatitis" 139 : 69-81, 1974

8 Banks PA, "Practice Parameters Committee of the American College of Gastroenterology. Practice guidelines in acute pancreatitis" 101 : 2379-2400, 2006

9 Johnson CD, "Persistent organ failure during the first week as a marker of fatal outcome in acute pancreatitis" 531340-531344, 2004

10 Beger HG, "Natural course of acute pancreatitis" 21 : 130-135, 1997

11 Nathens AB, "Management of the critically ill patient with severe acute pancreatitis" 32 : 2524-2536, 2004

12 Werner J, "Management of acute pancreatitis: from surgery to interventional intensive care" 54 : 426-436, 2005

13 Wemer J, "Management of acute pancreatitis: from surgery to interventional intensive care" 54 : 426-436, 2005

14 Uhl W, "IAP guidelines for surgical management of acute pancreatitis" 2 : 565-573, 2002

15 Blum T, "Fatal outcome in acute pancreatitis: Its occurrence and early prediction" 1 : 237-241, 2001

16 Mouli VP, "Efficacy of Conservative Treatment, Without Necrosectomy, for Infected Pancreatic Necrosis: A Systemic Review and Meta-analysis" 144 : 333-340, 2013

17 Mier J, "Early versus late necrosectomy in severe necrotizing pancreatitis" 173 : 71-75, 1997

18 Bone RC, "Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. 1992" 101 : 1644-1655, 1992

19 Fernández-del Castillo C, "Debridement and closed packing for the treatment of necrotizing pancreatitis" 228 : 676-684, 1998

20 United Kingdom guidelines for the management of acute pancreatitis, "British Society of Gastroenterology" 42 : S1-S13, 1998

21 Isenmann R, "Bacterial infection and extent of necrosis are determinants of organ failure in patients with acucte necrotizing pancreatitis" 86 : 1020-1024, 1999

22 Garg PK, "Association of extent and infection of pancreatic necrosis with organ failure and death in acute necrotizing pancreatitis" 3 : 159-166, 2005

23 Balthazar EJ, "Acute pancreatitis ; value of CT in establishing prognosis" 174 : 331-336, 1990

24 Büchler MW, "Acute necrotizing pancreatitis: treatment strategy according to the status of infection" 232 : 619-626, 2000

25 Forsmark CE, "AGA institute technical review on acute pancreatitis" 132 : 2022-2044, 2007

26 Van Santvoort HC, "A step up approach or open necrosectomy for necrotizing pancreatitis" 362 : 1491-1502, 2010

27 Bradley EL 3rd, "A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992" 128 : 586-590, 1993

28 Van Santvoort HC, "A Conservative and Minimally Invasive Approach to Necrotizing Pancreatitis Improves Outcome" 141 : 1254-1263, 2011