일시적 방광 과신장에 의한 토끼 방광의 조직학적 변화 = The Histologic Changes after Transient Overdistension in the Rabbit Bladder

다국어 초록 (Multilingual Abstract)

Background : Morphological changes of bladder wall and innervated nerve after prolonged overdistension on bladder wall have been shown by previous studies. Since there are few studies about transient overdistension, these studies were focused to investigate morphologic changes after transient overdistension
Methods : 18 male New Zealand White rabbit bladder were distended for 15 minutes with catheter. After transient overdistension histopathologic studies (H-E stain, S-100 protein stain) were performed in 3 rabbits of the study group at controls, immediate, 1, 3, 7, 14 day.
Results : H-E stain; mucosal necrosis and vacuolization in the mucosa were seen at immediate, mostly increased after 3 day, decreased after 7 day and disappeared after 14 day. Edema was seen at immediate in the submucosa and muscle layer, mostly increased after 1 day, decreased after 3 days and after 7 days, fibrosis was seen in the submucosa and muscle layer. Hemorrage was in submucosa after 1 day and disappeared after 3 day.
S-100 protein; Expression of S-100 protein was decreased than those of the control group after 1,3 day, recovered after 7 day and almost similar after 14 day.
Conclusion : Transient overdistension causes damage to mucosa, submucosa, muscle layer and innervated nerve. Bladder wall however is, almost completely healed within 7 day and innervated nerve healed within 14 day.