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      본태성 고혈압쥐(SHR)에서 현미 식물성스테롤의 혈압 및 지질 대사 개선 효과 = Brown Rice Phytosterol Improves Hypertension and Lipid Metabolism in Spontaneously Hypertensive Rats

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      https://www.riss.kr/link?id=A99566533

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      다국어 초록 (Multilingual Abstract)

      This study was conducted to investigate the effects of brown rice and brown rice phytosterol on blood pressure and lipid levels in spontaneously hypertension rats (SHR). SHR were grouped according to blood pressure and fed either a control diet or experimental diets containing 50% brown rice powder or 5% brown rice phytosterol for 3 weeks. Body weight gain and epididymal fat weight were significantly reduced in the brown rice powder and brown rice phytosterol groups compared to control. Brown rice and brown rice phytosterol diets suppressed age-dependent increases in systolic blood pressure compared to control. In addition, brown rice and brown rice phytosterol diets decreased total lipid, triglyceride, and cholesterol levels in the liver, whereas serum HDL cholesterol increased. Lastly, brown rice phytosterol reduced TBARS contents in the kidney. These results suggest that brown rice and brown rice phytosterol exert antihypertensive effects that improve lipid metabolism in SHR.
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      This study was conducted to investigate the effects of brown rice and brown rice phytosterol on blood pressure and lipid levels in spontaneously hypertension rats (SHR). SHR were grouped according to blood pressure and fed either a control diet or exp...

      This study was conducted to investigate the effects of brown rice and brown rice phytosterol on blood pressure and lipid levels in spontaneously hypertension rats (SHR). SHR were grouped according to blood pressure and fed either a control diet or experimental diets containing 50% brown rice powder or 5% brown rice phytosterol for 3 weeks. Body weight gain and epididymal fat weight were significantly reduced in the brown rice powder and brown rice phytosterol groups compared to control. Brown rice and brown rice phytosterol diets suppressed age-dependent increases in systolic blood pressure compared to control. In addition, brown rice and brown rice phytosterol diets decreased total lipid, triglyceride, and cholesterol levels in the liver, whereas serum HDL cholesterol increased. Lastly, brown rice phytosterol reduced TBARS contents in the kidney. These results suggest that brown rice and brown rice phytosterol exert antihypertensive effects that improve lipid metabolism in SHR.

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      참고문헌 (Reference)

      1 구본순, "식물스테롤 처리가 흰쥐의 혈장지질 및 혈당농도에 미치는 영향" 한국식생활문화학회 19 (19): 429-, 2004

      2 최희돈, "발아현미의 본태성 고혈압쥐에 대한 혈압강하 효과" 한국식품과학회 38 (38): 448-451, 2006

      3 Kannel WB, "components of blood pressure and risk of atherothrombotic brain infarction" 7 : 327-331, 1976

      4 Justo ML, "Watersoluble rice bran enzymatic extract attenuates dyslipidemia, hypertension and insulin resistance in obese Zucker rats" 2012

      5 Miller NE., "The evidence for the antiatherogenicity of high density lipoprotein in man" 1978

      6 Baker WL, "The effect of plant sterols or stanols on lipid parameters in patients with type 2 diabetes: a meta-analysis" 84 (84): e33-e37, 2009

      7 Ardiansyah, "The Driselase-treated fraction of rice bran is a more effective dietary factor to improve hypertension, glucose and lipid metabolism in stroke-prone spontaneously hypertensive rats compared to ferulic acid" 97 (97): 67-76, 2007

      8 Ling WH, "Supplementation of the black rice outer layer fraction to rabbits decreases atherosclerotic plaque formation and increases antioxidant status" 132 (132): 20-26, 2002

      9 Lee YR, "Studies of functional foods using giant embryonic rice" Kyungpook National University

      10 Suzuki A, "Short- and long-term effects of ferulic acid on blood pressure in spontaneously hypertensive rats" 15 (15): 351-357, 2002

      1 구본순, "식물스테롤 처리가 흰쥐의 혈장지질 및 혈당농도에 미치는 영향" 한국식생활문화학회 19 (19): 429-, 2004

      2 최희돈, "발아현미의 본태성 고혈압쥐에 대한 혈압강하 효과" 한국식품과학회 38 (38): 448-451, 2006

      3 Kannel WB, "components of blood pressure and risk of atherothrombotic brain infarction" 7 : 327-331, 1976

      4 Justo ML, "Watersoluble rice bran enzymatic extract attenuates dyslipidemia, hypertension and insulin resistance in obese Zucker rats" 2012

      5 Miller NE., "The evidence for the antiatherogenicity of high density lipoprotein in man" 1978

      6 Baker WL, "The effect of plant sterols or stanols on lipid parameters in patients with type 2 diabetes: a meta-analysis" 84 (84): e33-e37, 2009

      7 Ardiansyah, "The Driselase-treated fraction of rice bran is a more effective dietary factor to improve hypertension, glucose and lipid metabolism in stroke-prone spontaneously hypertensive rats compared to ferulic acid" 97 (97): 67-76, 2007

      8 Ling WH, "Supplementation of the black rice outer layer fraction to rabbits decreases atherosclerotic plaque formation and increases antioxidant status" 132 (132): 20-26, 2002

      9 Lee YR, "Studies of functional foods using giant embryonic rice" Kyungpook National University

      10 Suzuki A, "Short- and long-term effects of ferulic acid on blood pressure in spontaneously hypertensive rats" 15 (15): 351-357, 2002

      11 Ardiansyah, "Rice bran fractions improve blood pressure, lipid profile, and glucose metabolism in strokeprone spontaneously hypertensive rats" 54 (54): 1914-1920, 2006

      12 Toyokuni S, "Protective effect of colored rice over white rice on Fenton reactionbased renal lipid peroxidation in rats" 36 (36): 583-592, 2002

      13 Miettinen TA, "Plant stanol and sterol esters in prevention of cardiovascular diseases" 36 (36): 126-134, 2004

      14 Miettinen TA, "Plant stanol and sterol esters in prevention of cardiovascular diseases" 36 (36): 126-134, 2004

      15 Houston MC, "Nutraceuticals, vitamins, antioxidants, and minerals in the prevention and treatment of hypertension" 47 (47): 396-449, 2005

      16 Dominiczak AF, "Nitric oxide and its putative role in hypertension" 25 (25): 1202-1211, 1995

      17 Jones PJ, "Modulation of plasma lipid levels and cholesterol kinetics by phytosterol versus phytostanol esters" 41 (41): 697-705, 2000

      18 de Jong A, "Metabolic effects of plant sterols and stanols" 14 : 362-369, 2003

      19 Patil GS, "Intergradical oxidation of α- tocopherol the surface properties of its oxidation products" 19 : 416-422, 1978

      20 Jung EH, "Hypoglycemic effects of a phenolic acid fraction of rice bran and ferulic acid in C57BL/KsJ-db/db mice" 55 (55): 9800-9804, 2007

      21 Ehlers PI, "High blood pressure-lowering and vasoprotective effects of milk products in experimental hypertension" 106 (106): 1353-1363, 2011

      22 Sáez GT, "Factors related to the impact of antihypertensive treatment in antioxidant activities and oxidative stress by-products in human hypertension" 17 (17): 809-816, 2004

      23 Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. ., "Executive Summary of The Third Report of The National Cholesterol Education Program(NCEP)Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults(Adult Treatment Panel III)" JAMA 2001

      24 Hallikainen M, "Endothelial function in hypercholesterolemic subjects: Effects of plant stanol and sterol esters" 188 (188): 425-432, 2006

      25 Rhee SJ, "Effects of vitamin E and selenium on the antioxidantative defense system in STZ-induced diabetes rats" 29 : 22-31, 1996

      26 Lai MH, "Effects of rice bran oil on the blood lipids profiles and insulin resistance in type 2 diabetes patients" 51 (51): 15-18, 2012

      27 Billingsley M, "Effects of peripherally administered GABA and other amino acids on cardiopulmonary responses in anesthetized rats and dogs" 255 : 131-140, 1982

      28 Kim BH, "Dietary structured lipids and phytosteryl esters: blood lipids and cardiovascular status in spontaneously hypertensive rats" 43 (43): 55-64, 2008

      29 Ha TY, "Changes in nutraceutical lipid components of rice at different degrees of milling" 108 : 175-181, 200603

      30 Lee MH, "Change physicochemical properties and mineral contents during buckwheat germination" 7 : 267-273, 1994

      31 Bartnick M, "Change in phatase content and phytase during the germination of some cereals" 5 : 23-28, 1987

      32 Jakala P, "Cardiovascular activity of milk casein-derived tripeptides and plant sterols in spontaneously hypertensive rats" 60 (60): 11-20, 2009

      33 Inoue K, "Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives" 57 (57): 490-495, 2003

      34 Hallfrisch J, "Blood pressure reduced by whole grain diet containing barley or whole wheat and brown rice in moderately hyperchoelsterolemic men" 23 : 1631-1642, 2003

      35 Ohkawa H, "Assay for lipid peroxides in animal tissues by thiobartituric acid reaction" 95 : 35-41, 1979

      36 Choi SW, "Antioxidant activit of ethanolic extracts of rice brans" 5 : 305-309, 1996

      37 Woyengo TA, "Anticancer effects of phytosterols" 63 (63): 813-820, 2009

      38 Hernandez-Ledesma B, "Angiotensin converting enzyme inhibitory activity in commercial fermented products. Formation of peptides under simulated gastrointestinal digestion" 52 (52): 1504-1510, 2004

      39 Fukuda S, "Age-related changes in blood pressure, hematological values, concentrations of serum biochemical constituents and weights of organs in the SHR/Izm, SHRSP/Izm and WKY/Izm" 53 (53): 67-72, 2004

      40 Folch J, "A simple method for the isolation and purification of total lipids from animal tissues" 226 : 497-509, 1957

      41 Chen CW, "A rice bran oil diet increases LDLreceptor and HMG-CoA reductase mRNA expressions and insulin sensitivity in rats with streptozotocin/ nicotinamide-induced type 2 diabetes" 136 (136): 1472-1476, 2006

      42 Rocha M, "A review on the role of phytosterols: new insights into cardiovascular risk" 17 (17): 4061-4075, 2011

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2026 평가예정 재인증평가 신청대상 (재인증)
      2020-01-01 평가 등재학술지 유지 (재인증) KCI등재
      2017-01-01 평가 등재학술지 유지 (계속평가) KCI등재
      2014-12-16 학술지명변경 외국어명 : Journal of The Korean Society of Dietary Culture -> Journal of The Korean Society of Food Culture KCI등재
      2013-01-01 평가 등재 1차 FAIL (등재유지) KCI등재
      2010-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2008-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2005-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2004-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2003-01-01 평가 등재후보 1차 FAIL (등재후보1차) KCI등재후보
      2002-01-01 평가 등재후보학술지 유지 (등재후보1차) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.8 0.8 0.87
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.87 0.89 1.461 0.11
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