비알코올 지방간질환의 진단 = PG 2 : Diagnosis ; Diagnostic Evaluation of Non-alcoholic Fatty Liver Disease

다국어 초록 (Multilingual Abstract)

The different prognosis of NAFLD histological subtypes leads to needs for screening all NAFLD patients for the presence of NASH, with or without advanced fibrosis. Liver biopsy remains as gold standard to identify the presence of steatohepatitis and fibrosis in patients with NAFLD, but it has limitations. Therefore, several non-invasive approaches using combine clinical and biochemical parameters into quantitative panels or radiological techniques to assess liver disease severity in NAFLD have been proposed. Among them, NAFLD Fibrosis Score and transient elastography are clinically useful tools for identifying NAFLD patients with higher likelihood of having advanced fibrosis. Noninvasive biochemical parameters and panels could be helpful in decision for liver biopsy in diagnosis of NASH in patients with a high probability of progressive disease after non-invasive assessment and reduce the need for liver biopsy. However, an important limitation of these non-invasive methods is that they were all validated in a cross-sectional fashion, so their accuracy to monitor disease progression and treatment response remains largely unknown.