골절 후 골다공증의 약물치료 및 낙상 예방 = Medical Treatment of Osteoporosis/Prevention of Falls

국문 초록 (Abstract)

평균 수명의 연장에 의한 골다공증성 골절 환자의 증가는 치료하는 정형외과 의사뿐만 아니라 사회 경제적으로도 부담이 되고 있다. 고령층에서 발생하는 골절의 치료는 젊은 환자의 골절 치료에 비하여 수술 전 고려 사항도 복잡하고, 수술 후 적절한 전신 상태 관리와 더불어 이차적인 골절을 예방해야 하므로 보다 체계적인 접근이 필요하다. 이 장에서는 골다공증성 골절 후 이차적인 골절을 예방하기 위한 약물 치료와 낙상 예방을 위한 전략에 대하여 기술하고자 한다.

다국어 초록 (Multilingual Abstract)

The prevention and treatment of fragility fractures is evolving continuously. Adequate fracture care should involve treating the fracture itself as well as the underlying bone disease. Although effective treatments of osteoporosis are available, a large proportion of patients with fragility fractures are not prescribed anti-osteoporotic medications after their injury. Recent advances in diagnostic tools and medications allow for a more effective and comprehensive treatment of fragility fractures.

참고문헌 (Reference)

1 양규현, "골대사 약물과 골절 치료기전과의 상호 관계" 대한골절학회 24 (24): 212-216, 2011

2 장재석, "골다공증 골절의 약물 요법" 대한골절학회 23 (23): 326-340, 2010

3 Lyles KW, "Zoledronic acid and clinical fractures and mortality after hip fracture" 357 : 1799-1809, 2007

4 Panneman MJ, "Undertreatment with anti-osteoporotic drugs after hospitalization for fracture" 15 : 120-124, 2004

5 Lewiecki EM, "Two-year treatment with denosumab (AMG 162) in a randomized phase 2 study of postmenopausal women with low BMD" 22 : 1832-1841, 2007

6 Andrews EB, "The US postmarketing surveillance study of adult osteosarcoma and teriparatide: study design and findings from the first 7 years" 27 : 2429-2437, 2012

7 Aspenberg P, "Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures" 25 : 404-414, 2010

8 Tsai JN, "Teriparatide and denosumab, alone or combined, in women with postmenopausal osteoporosis: the DATA study randomised trial" 382 : 50-56, 2013

9 Min BW, "Scoring system for identifying impending complete fractures in incomplete atypical femoral fractures" 102 : 545-550, 2017

10 Marsh JL, "Rockwood and Green's fractures in adults" Lippincott 621-650, 2016

11 Peichl P, "Parathyroid hormone 1-84 accelerates fracture-healing in pubic bones of elderly osteoporotic women" 93 : 1583-1587, 2011

12 우제현, "Osteoporotic Fracture: 2015 Position Statement of the Korean Society for Bone and Mineral Research" 대한골대사학회 22 (22): 175-181, 2015

13 Amanat N, "Optimal timing of a single dose of zoledronic acid to increase strength in rat fracture repair" 22 : 867-876, 2007

14 Lord SR, "Multifocal glasses impair edge-contrast sensitivity and depth perception and increase the risk of falls in older people" 50 : 1760-1766, 2002

15 김경민, "Medication Related Osteonecrosis of the Jaw: 2015 Position Statement of the Korean Society for Bone and Mineral Research and the Korean Association of Oral and Maxillofacial Surgeons" 대한골대사학회 22 (22): 151-165, 2015

16 Grossman DC, "Interventions to prevent falls in community-dwelling older adults: US preventive services task force recommendation statement" 319 : 1696-1704, 2018

17 Gillespie LD, "Interventions for preventing falls in older people living in the community" (9) : 2012

18 Cumming RG, "Improving vision to prevent falls in frail older people: a randomized trial" 55 : 175-181, 2007

19 Chu LW, "Falls and fall-related injuries in community-dwelling elderly persons in Hong Kong: a study on risk factors, functional decline, and health services utilisation after falls" 13 (13): S8-S12, 2007

20 Goldhahn J, "Evidence for anti-osteoporosis therapy in acute fracture situations: recommendations of a multidisciplinary workshop of the International Society for Fracture Repair" 46 : 267-271, 2010

21 Pfeifer M, "Effects of a long term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals" 20 : 315-322, 2009

22 Bischoff-Ferrari HA, "Effect of vitamin D on falls: a meta-analysis" 291 : 1999-2006, 2004

23 Han SL, "Effect of teriparatide on bone mineral density and fracture in postmenopausal osteoporosis: meta-analysis of randomised controlled trials" 66 : 199-209, 2012

24 Hegde V, "Effect of osteoporosis medications on fracture healing" 27 : 861-871, 2016

25 임군일, "Effect of Teriparatide on Healing of Atypical Femoral Fractures: A Systemic Review" 대한골대사학회 22 (22): 183-189, 2015

26 Adami S, "Denosumab treatment in postmenopausal women with osteoporosis does not interfere with fracture-healing: results from the FREEDOM trial" 94 : 2113-2119, 2012

27 Cummings SR, "Denosumab for prevention of fractures in postmenopausal women with osteoporosis" 361 : 756-765, 2009

28 Black DM, "Clinical practice. Postmenopausal osteoporosis" 374 : 254-262, 2016

29 김경민, "Calcium and Vitamin D Supplementations: 2015 Position Statement of the Korean Society for Bone and Mineral Research" 대한골대사학회 22 (22): 143-149, 2015

30 양규현, "Atypical Femoral Fracture: 2015 Position Statement of the Korean Society for Bone and Mineral Research" 대한골대사학회 22 (22): 87-91, 2015

31 Eriksen EF, "Antifracture efficacy and reduction of mortality in relation to timing of the first dose of zoledronic acid after hip fracture" 24 : 1308-1313, 2009

32 Moroni A, "Alendronate improves screw fixation in osteoporotic bone" 89 : 96-101, 2007