봉독이 간경화 동물 모델에 미치는 영향

다국어 초록 (Multilingual Abstract)

Liver fibrosis is characterized by the excessive accumulation of extracellular matrix (ECM). Bee venom has been utilized as pain reliever and as treatment against inflammatory diseases since ancient times.
This study elucidates the changes of bee venom treated during liver fibrogenesis by CCl₄. In this experiment, the alanine aminotransferase (AST) and aspartate aminotransterase (ALT) reduced the group having hepatic damage with fibrosis treated with bee venom cone. 0.05 ㎎/㎏ and 0.1 ㎎/㎏ compared with those of liver damage group. Tumor necrosis factor-a (TNF-α) activity reduced the groups having hepatic damage with fibrosis treated with bee venom. However the group having hepatic damage with fibrosis treated with bee venom conc. 0.5 ㎎/㎏ increased AST and ALT compared with other groups, high bee venom caused toxicity. The transforming growth factor-B) (TGF-β1), a-smooth muscle actin (α-SMA) and fibronectin reduced the group having hepatic damage with fibrosis treated with bee venom cone. 0.05 ㎎/㎏ and 0.1 ㎎/㎏, 0.5 ㎎/㎏ compared with those of liver damage group.
These results indicate that bee venom efficiently decreased AST, ALT, TNF-α TGF-β1, α-SMA and fibronectin, and suggest that such an approach may represent an interesting therapeutic alternative toward the treatment of liver cirrhosis.

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