Programmed death‐ligand‐1 (PD‐L1) is a ligand for programmed death receptor (PD‐1) that plays a major role in cell‐mediated immune response; it regulates T‐cell activation and regulates survival and functions of activated T cells. Expressi...
http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
https://www.riss.kr/link?id=O111701185
2021년
-
2041-1006
2041-1014
SCI;SCIE;SCOPUS
학술저널
172-181 [※수록면이 p5 이하이면, Review, Columns, Editor's Note, Abstract 등일 경우가 있습니다.]
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
Programmed death‐ligand‐1 (PD‐L1) is a ligand for programmed death receptor (PD‐1) that plays a major role in cell‐mediated immune response; it regulates T‐cell activation and regulates survival and functions of activated T cells. Expressi...
Programmed death‐ligand‐1 (PD‐L1) is a ligand for programmed death receptor (PD‐1) that plays a major role in cell‐mediated immune response; it regulates T‐cell activation and regulates survival and functions of activated T cells. Expression of PD‐L1 can induce chronic inflammation and activate mechanisms of immune evasion. PD‐L1 is expressed in most of human carcinomas. Porphyromonas gingivalis (P. gingivalis) is a major keystone pathogen in periodontitis that invade host cells and disposes a variety of virulence factors. The aim of the present study was to clarify the signaling pathway of P. gingivalis molecules that induce PD‐L1 up‐regulation in colon carcinoma cells. Additionally, it was investigated which components of P. gingivalis are responsible for PD‐L1 induction. Colon cancer cells (CL‐11) were stimulated with total membrane (TM) fractions, peptidoglycans (PDGs) and viable P. gingivalis bacteria. Seven signaling molecule inhibitors were used: receptor‐interacting serine/threonine‐protein kinase 2 (RIP2) tyrosine kinase inhibitor, nucleotide‐binding oligomerization domain (NOD)‐like receptor 1&2 inhibitor, NOD‐like receptor, nuclear factor kappa B inhibitor, c‐Jun N‐terminal kinases inhibitor, mitogen‐activated protein/extracellular signal‐regulated kinase inhibitor, mitogen activated kinase (MAPK) inhibitor. PD‐L1 protein expression was examined by western blot analysis and quantitative real time PCR. It was demonstrated that the TM fraction and PDG induced up‐regulation of PD‐L1 expression in colon cancer cells. In conclusion, the results of this study suggest that PDG of P. gingivalis plays a major role in PD‐L1 up‐regulation in colon cancer cells. In addition, the mechanism of PD‐L1 up‐regulation depends on NOD 1 and NOD 2 and involves activation of RIP2 and MAPK signaling pathways.
The multifaceted roles of antimicrobial peptides in oral diseases