Molecular Analysis of TGF-β1-induced BAFF Promoter Activity in Mouse Antigen Presenting Cells

다국어 초록 (Multilingual Abstract)

BAF, one of the TNF ligand family, is primarily expresed by APCs such as macrophages eration, differentiation, survival, a n d I g p r o d u c t i o n o f B c e l s . I n t h e p r e s e n t s t u d y , w e a i m e d t o elucidate the molecular mechanisms by which TGF-1 induce BAFF expresion in order to gain a clue if TGF-1 may regulate B cell differentiation through influencing APCs. We found that TGF-1 pical TGF- signaling pathway is involved. Thus, Smad3 and Smad4 promoted BAF promoter activity in mouse dendritic cels and macrophages. Further, from the analysis of the BAF mutated promoters, we identified three putative Smad binding elements (SBEs) where Smad3 actually binds. These elements were indispensable for the promoter activity.

참고문헌 (Reference)

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