과체중 여성에서 L-carnitine과 Isoflavone 보충 섭취가 체중 및 내장지방 감소에 미치는 영향 = The Effect of L-Carnitine and Isoflavone Supplementation on Weight Reduction and Visceral Fat Accumulation in Overweight Women

다국어 초록 (Multilingual Abstract)

This study was performed to examine the combined effects of L-carnitine and isoflavone supplementation on weight reduction and body fat distribution in overweight women. Overweight/obese women (body mass index ＞ 23 ㎏/㎡) who were not diagnosed any type of diseases were included in this study and sixty subjects (41.1 ± 1.5 years, 25.9 ± 0.3 ㎏/㎡) were randomly assigned to a placebo (n = 30) or a supplement group (n = 30, L-carnitine 300 ㎎+isoflavone 40 ㎎/day). We measured anthropometric parameters, abdominal fat distribution by computerizd tomography and blood components before and after the 12 week intervention period. After the 12 weeks of supplementation, subjects in L-car-nitine and isoflavone supplement group showed a significant reduction of body weight (p ＜ 0.001), body fat % (p ＜ 0.05), and waist to hip ratio (p ＜ 0.01) whereas placebo group did not show any changes. In a CT-scanned results, total fat area at L4 level was significantly reduced by 8.1 % (p ＜ 0.01) with the reduction of visceral fat area (-11.1 %, p ＜ 0.001) and subcutaneous fat area (-7.0%, p ＜ 0.05) in the supplement group. The supplementation of L-carnitine and isoflavone showed the significant improvement of HDL-C (p ＜ 0.01) and apoB (p ＜ 0.05) concentrations, however, change values in those markers were not significant compared with those of the placebo group. In addition, a significant increase of adiponectin level (p ＜ 0.001) was observed in the supplement group after the intervention. The result of present study demonstrated that supplementation of 300 ㎎ L-carnitine and 40 mg isoflavone per day for 12 weeks can give beneficial effects on weight reduction and visceral fat accumulation. These potential antiobesity supplement can produce more favorable effects when combined with lifestyle modification.

목차 (Table of Contents)

• ABSTRACT
• 서론
• 대상자 및 연구방법
• 결과
• 고찰
• 요약 및 결론
• 감사의 글
• Literature cited

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