Niacin (Vitamin B3) is a necessary nutrient for humans and animals. This study was conducted to examine the effect of niacin on osteoblast differentiation. Previous study shows that precursor of niacin suppress osteoclast formation. However, the mecha...
Niacin (Vitamin B3) is a necessary nutrient for humans and animals. This study was conducted to examine the effect of niacin on osteoblast differentiation. Previous study shows that precursor of niacin suppress osteoclast formation. However, the mechanism of niacin in osteoblast differentiation is not well known. In this study we investigated the effect of niacin in osteoblasts. Niacin induced osteogenic differentiation marker genes including distal-less homeobox 5(Dlx5), runt-related transcription factor 2(Runx2), alkaline phosphatase(ALP), and osteocalcin(OC). These results suggest that niacin contributes to osteoblast differentiation by inducing the osteogenic genes.