Incidence and Prevalence of Overt Hypothyroidism and Causative Diseases in Korea as Determined Using Claims Data Provided by the Health Insurance Review and Assessment Service

다국어 초록 (Multilingual Abstract)

Background: The incidence and prevalence of overt hypothyroidism have been reported to be 2 to 4/1,000 population/year and 8 to 13/1,000 population, respectively, in foreign countries. As there has been no nationwide survey to obtain data in Korea, the present study investigated the incidence and prevalence of overt hypothyroidism in Korea using claims data provided by the Health Insurance Review and Assessment Service. The proportions of causative diseases for hypothyroidism were also analyzed.
Methods: This study was retrospectively performed with 541,969 Korean patients (92,832 men and 449,137 women), with overt hypothyroidism, treated with thyroid hormone between 2008 and 2012.
Results: The incidence of overt hypothyroidism in Korea was 2.26/1,000 population/year (0.78 in men and 3.72 in women), and the prevalence was 14.28/1,000 population (4.40 in men and 24.03 in women). When patients with thyroid cancer were excluded, the incidence was 1.56/1,000 population/year (0.54 in men and 2.57 in women). The incidence increased with age, with peaks in and after the late 60s in men and in the early 50s in women. The prevalence peaked in the early 70s in men and in the late 50s in women.
Conclusion: This is a report of the first nationwide investigation of the incidence and prevalence of overt hypothyroidism in Korea, although it is limited to patients treated with thyroid hormone.

참고문헌 (Reference)

1 서기현, "건강보험심사평가원 자료로 분석한 우리나라 갑상선기능항진증의 발생률/유병률 조사와 치료법 선호도의 분석" 대한갑상선학회 6 (6): 56-63, 2013

2 Jung CH, "Thyroid dysfunction and their relation to cardiovascular risk factors such as lipid profile, hsCRP, and waist hip ratio in Korea" 18 : 146-153, 2003

3 Tunbridge WM, "The spectrum of thyroid disease in a community: the Whickham survey" 7 : 481-493, 1977

4 Vanderpump MP, "The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey" 43 : 55-68, 1995

5 Bilous RW, "The epidemiology of hypothyroidism: an update" 2 : 531-540, 1988

6 Canaris GJ, "The Colorado thyroid disease prevalence study" 160 : 526-534, 2000

7 Wiersinga WM, "Subclinical hypothyroidism and hyperthyroidism. I. Prevalence and clinical relevance" 46 : 197-204, 1995

8 Hollowell JG, "Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III)" 87 : 489-499, 2002

9 Lee WY, "Relationship between subclinical thyroid dysfunction and femoral neck bone mineral density in women" 37 : 511-516, 2006

10 Chung JH, "Prevalence of thyrotoxicosis and hypothyroidism in the subjects for health check-up" 14 : 301-313, 1999

11 Oh MK, "Prevalence of thyroid diseases among adult for health check-up in a Youngdong area of Kwangwon province" 22 : 1363-1374, 2001

12 Choi HS, "Prevalence of subclinical hypothyroidism in two population based-cohort: Ansung and KLoSHA cohort in Korea" 3 : 32-40, 2010

13 김예안, "Prevalence and Risk Factors of Subclinical Thyroid Disease" 대한내분비학회 29 (29): 20-29, 2014

14 Vanderpump MP, "Epidemiology and prevention of clinical and subclinical hypothyroidism" 12 : 839-847, 2002

15 Kim TH, "Effect of seasonal changes on the transition between subclinical hypothyroid and euthyroid status" 98 : 3420-3429, 2013

16 최재경, "55세 이상 여성에서 무증상 갑상선기능저하증과 심혈관 위험요인" 대한가정의학회 23 (23): 96-103, 2002