여성 과민성방광 환자에서 tamsulosin과 tolterodine 병합치료의 효과 = The efficacy of tamsulosin and tolterodine combination therapy in female OAB patients

다국어 초록 (Multilingual Abstract)

Introduction and Objective : Although, first-line drug in medical treatment of female overactive bladder (OAB) is anti-muscarinic agents such as tolterodine, addition of tamsulosin in empirical base is also used. We evaluated the efficacy of tolterodine and tamsulosin combination therapy in female OAB patients
Methods : Between January 2009 and December 2009, a study was carried out on 80 female patients with newly diagnosed OAB. The patients were separated to two groups according to treatment regimens and evaluated the efficacy of tolterodine (2mg) and tamsulosin (0.2mg) combination therapy with tolterodine alone.
Before and after 6 weeks of treatment, all patients were evaluated with 3 days of voiding diary, uroflowmetry (UFM) including postvoiding residual urine volume (PVR) and QOL index in IPSS. The treatment efficacy was measured with mean number of micturition, nocturia and urgency, mean voided volume, maximal flow rate (Qmax), PVR and QOL index.
Results : There were no statistical differences in evaluation factors between monotherapy group (Group I, n=38) and combination therapy group (Group II, n=37) before treatment. After 6 weeks of treatment, mean number of micturition and urgency, mean voided volume, and QOL index were improved in both groups. But there were no statistical differences in improved factors after treatment between the two groups. The Qmax increased when compared to baseline Qmax in Group II there were no changes in Qmax of Group I after treatment.
In subgroup analysis of the patients with decreased Qmax (≤12ml/sec), the combination therapy group showed much improvement in mean number of micturition, Qmax, and QOL index when compared to monotherapy group.
Five patients who stopped medication due to side effect (two with dry mouth, three with orthostatic hypotension) were excluded in this study.
Conclusions : From this study, there were no comparative advantages in combination treatment with tamsulosin when compared to tolterodine monotherapy except maximal flow rate. But, there were some addictive effects of combination therapy in subgroup of patients with decreased Qmax. Further research including placebo group and urodynamic study may provide more accurate result about the efficacy of tamsulosin in female OAB patients.

목차 (Table of Contents)

• Abstract v
• I. 서 론 1
• II. 대상 및 방법 3
• 1. 대상 및 방법 3
• 2. 통계처리 4
• III. 결 과 5
• IV. 고 찰 7
• V. 결 론 13
• VI. 참고문헌 14
• Figures and Tables 19