스코폴라민 유도 기억력 손상 모델에서 새싹산양삼과 이를 포함한 경옥고 가미방의 기억력 개선 효과 = Effects of Ginseng Sprout Extract and Modified Kyung-Ok-Ko on Scopolamine-induced Cognitive Impairment in Mice Park, H.

다국어 초록 (Multilingual Abstract)

As the world population ages, the number of patients with dementia is expected to increase dramatically in the future. Ginseng (Panax ginseng C.A. Meyer) has many effects such as control of nerve function, control of body fluids and metabolic function, anti-diuretic, sexual enhancement, resistance to stress, improvement of digestion and absorption, and immune boosting effects.
Kyung-Ok-Ko is widely used in traditional Korean medicine. The aim of this study is to investigate memory-enhancing properties of 70% ethanolic extracts of ginseng sprouts and modified Kyung-Ok-Ko. Alzheimer’s disease was induced by scopolamine treatment (1 mg/kg, i.p.) in mice.
Passive avoidance and Y-maze tasks were performed by the mice to determine the effects of ginseng sprout extract and modified Kyung-Ok-Ko on memory. Ginseng sprout extract and modified Kyung-Ok-Ko significantly enhanced cognitive function and reduced scopolamineinduced cognitive impairment in mice. Compared to Kyung-Ok-Ko, modified Kyung-Ok-Ko had a significant memory-enhancing effect at a lower dose. Our findings suggest that ginseng sprout extract and modified Kyung-Ok-Ko attenuate cognitive impairment in mice.

참고문헌 (Reference)

1 임태진, "인삼 및 산양삼의 항산화 효능 비교 -Superoxide radical과 Hydroxy radical 소거활성을 중심으로-" 대한약침학회 12 (12): 7-12, 2009

2 김영섭, "에탄올 투여로 유도한 생쥐의 인지기능 손상에 대한 길경 추출물의 개선효능" 한국생약학회 35 (35): 239-243, 2004

3 제갈경환, "스코폴라민으로 유도된 기억력 손상에 대한 복신의 보호 효과 및 작용기전 연구" 한의병리학회 24 (24): 228-235, 2010

4 김종민, "마우스에서 흑지마 에탄올 추출물의 기억력 증진 효과 및 기억력 감퇴에 대한 개선 효과" 한국생약학회 41 (41): 196-203, 2010

5 원진배, "더덕 물 추출물과 에탄올 추출물의 인지능 개선 활성 비교" 대한약학회 58 (58): 287-293, 2014

6 김명동, "경옥고 효능 및 제법에 대한 문헌고찰" 대한한의학원전학회 24 (24): 51-64, 2011

7 Ae Young Lee, "Vascular Dementia" 의과학연구소 47 (47): 66-71, 2011

8 Joo, NS, "Various effect of Korean ginseng" 31 : 895-896, 2010

9 Elisabetta, B., "The inverted"U-shaped"dose-effect relationships in learning and memory : modulation of arousal and consolidation" 3 : 9-21, 2005

10 Dawson, G. R., "The effects of novel cholinesterase inhibitors and selective muscarinic receptor agonists in tests of reference and working memory" 57 : 143-, 1993

11 Shahidi, S., "The effect of reversivle inactination of the supramammillary nucleus on passive avoidance learning in rats" 152 : 81-, 2004

12 Ahn, J., "The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways" 373 : 545-549, 2008

13 Lindsay K, Caesar., "Synergy and antagonism in natural product exytracts: when 1+1 does not equal 2" 36 : 869-888, 2019

14 Subedi, L., "Sulforaphane-Enriched Broccoli Sprouts Pretreated by Pulsed Electric Fields Reduces Neuroinflammation and Ameliorates Scopolamine-Induced Amnesia in Mouse Brain through Its Antioxidant Ability via Nrf2-HO-1 Activation" 2019 : 3549274-, 2019

15 Olton, D. S., "Spatial memory and hippocampal function" 17 : 669-682, 1979

16 Brookmeyer, R., "Projections of Alzheimer’s disease in the united states and the public health impact of delaying disease onset" 88 : 1337-1342, 1998

17 Burns, A., "Dementia" 338 : b75-, 2009

18 Polinsky, R. J., "Clinical pharmacology of rivastigmine : a new-generation acetylcholinesterase inhibitor for the treatment of Alzheimer’s disease" 20 : 634-647, 1998

19 Crapper, D. R., "Brain aging and Alzheimer’s disease" 23 : 229-233, 1978

20 Sarter, M., "Attenuation of scopolamine-induced impairment of spontaneous alteration behaviour by antagonist but not inverse agonist and agonist beta-carbolines" 94 : 491-495, 1988

21 Shin, B. Y., "Anti-amnesic effects of a herbal medicinal prescription modified from Kyung-Ok-Ko on Scopolamine- or transient forebrain Ischemia-Induced Memory Impairment" Kyung Hee University 2011

22 Reynolds, D. S., "A short perspective on the long road to effective treatments for Alzheimer’s disease" 176 : 3636-3648, 2019