Comparison of clinicopathological features and survival outcomes between type 1 and type 2 endometrial cancers = Comparison of clinicopathological features and survival outcomes between type 1 and type 2 endometrial cancers

다국어 초록 (Multilingual Abstract)

Objective: Endometrial cancers have been divided into estrogen-dependent type 1 (T1EC) and estrogen-independent type 2 (T2EC). We compared the clinicopathological characteristics and survival outcomes between T1EC and T2EC. In addition, we evaluated the outcomes of grade-3 tumors of T1EC (G3/T1EC) compared to those of T2EC.
Methods: Medical records of 462 cases of endometrial cancer with diagnosis from 2004 to 2013 and clinical course until 2018 was retrospectively reviewed. The tumor features, treatments, recurrence and death were compared between T1EC and T2EC group.
Results: There were 415 cases of T1EC and 47 cases of T2EC. Patients with T2EC were older (p=0.022) and menopausal (p=0.018), and less obese (p=0.041) than those with T1EC. T2EC had higher surgical stages (p=0.011) than T1EC. During a median follow-up of 128 months, T2EC was associated with shorter 5-year disease-free survival (5-y DFS) and overall survival (5-y OS) compared to T1EC (5-y DFS rate, 62% vs 86%, p=0.003; 5-y OS rate, 74% vs 91%, p=0.003). There was no significant difference in the mean age at diagnosis or surgical stage between T2EC and G3/T1EC (n=51). During a median follow-up of 116 months, 5-y DFS and OS of T2EC were similar to those of G3/T1EC (5-y DFS rate, 62% vs 66%, p=0.412; 5-y OS rate, 74% vs 81%, p=0.284).
Conclusion: T2EC was associated with older age and menopause compared to T1EC. T1EC tended to be diagnosed at earlier stage and have a favorable prognosis than T2EC. However, G3/T1EC showed similar clinicopathological features and survival outcomes to T2EC.