흰쥐의 급성 메스암페타민 투여에 대한 鍼의 효과 = The Effect of Acupuncture on Methamphetamine-induced Locomotor Activity and C-Fos Expression in Rat Brain

다국어 초록 (Multilingual Abstract)

Objectives : The mesolimbic dopamine system is believed to play a major role in the reinforcing effect and behavioral hyperactivity of abused drugs including methamphetamine. In the present study, the effect of acupuncture on methamphetamine-induced locomotor activity and c-Fos expression in the striatum and nucleus accumbens of rats were examined.
Methods : Male Sprague-Dawley rats received acupuncture at bilateral Yanggu(SI5) point for 30seconds immediately before the subcutaneous injection of saline or methamphetamine(0.5mg/kg). The total amount of locomotor activity for 90min were measured just before brain samples were taken for immunohistochemistry.
Results : Results showed that acupuncture at the specific point SI5, but not control point (Kunlun, BL60) significantly reduced locomotor activity and c-Fos expression in the striatum and nucleus accumbens induced by acute administration of methamphetamine.
Conclusions : These results suggest that acupuncture may be effective in suppressing the reinforcing effect of methamphetamine by regulating neuronal activity.

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