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      20세 이하 갑상선 유두암 환자의 임상 특징과 치료 결과 = Clinical Features and Outcomes of Papillary Thyroid Carcinoma in Patients Aged under 20

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      https://www.riss.kr/link?id=A101611041

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      Background and Objectives Thyroid carcinoma rarely occurs in children and adolescents, whose clinical features are diverse, and treatment outcomes are still controversial. The aim of this study was to evaluate the clinical features and the treatment o...

      Background and Objectives Thyroid carcinoma rarely occurs in children and adolescents, whose clinical features are diverse, and treatment outcomes are still controversial. The aim of this study was to evaluate the clinical features and the treatment outcomes of papillary thyroid carcinoma (PTC) patients younger than 20 years old.
      Subjects and Method This is a retrospective study for patients younger than 20 years old, who were diagnosed as PTC from January 1992 to February 2009. Clinical features, size, pathologic type, extrathyroidal extension, recurrence, multiplicity, extent of surgery, and lymph node metastasis were retrospectively evaluated.
      Results Forty patients, of 6 malse and 34 females, were enrolled, with their mean age being 16 years old. The initial operations were total thyroidectomy for 9 patients, unilateral lobectomy for 15 patients, and total thyroidectomy and lateral neck dissection for 16 patients. Cervical lymph node metastases were diagnosed in 25 patients. Extrathyroidal extensions were observed in 30 patients. Postoperative radioactive iodine therapy was performed in 35 patients. During the follow-up period, 8 patients had recurred. All patients were alive at the last follow-up.
      Conclusion PTC in children and adolescents aged under 20 is a rare disease and tends to present as an advanced disease with low mortality compared to adult PTC. Recurrence had no effect on survival. Aggressive treatment with total thyroidectomy, central neck dissection, and radioiodine therapy may prevent recurrence.

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      참고문헌 (Reference) 논문관계도

      1 이동근, "소아청소년 갑상선 분화암의 치료 결과" 대한이비인후과학회 55 (55): 435-439, 2012

      2 Segal K, "Welldifferentiated thyroid carcinoma" 17 (17): 401-406, 1996

      3 Wada N, "Treatment strategy of papillary thyroid carcinoma in children and adolescents: clinical significance of the initial nodal manifestation" 16 (16): 3442-3449, 2009

      4 Popovtzer A, "Thyroid cancer in children: management and outcome experience of a referral center" 135 (135): 581-584, 2006

      5 Haveman JW, "Surgical experience in children with differentiated thyroid carcinoma" 10 (10): 15-20, 2003

      6 Segal K, "Surgery of thyroid cancer in children and adolescents" 20 (20): 293-297, 1998

      7 Palmer BA, "Papillary thyroid carcinoma in children: risk factors and complications of disease recurrence" 40 (40): 1284-1288, 2005

      8 Brink JS, "Papillary thyroid cancer with pulmonary metastases in children: long-term prognosis" 128 (128): 881-886, 2000

      9 Schlumberger MJ, "Papillary and follicular thyroid carcinoma" 338 (338): 297-306, 1998

      10 Frankenthaler RA, "Lymph node metastasis from papillary-follicular thyroid carcinoma in young patients" 160 (160): 341-343, 1990

      1 이동근, "소아청소년 갑상선 분화암의 치료 결과" 대한이비인후과학회 55 (55): 435-439, 2012

      2 Segal K, "Welldifferentiated thyroid carcinoma" 17 (17): 401-406, 1996

      3 Wada N, "Treatment strategy of papillary thyroid carcinoma in children and adolescents: clinical significance of the initial nodal manifestation" 16 (16): 3442-3449, 2009

      4 Popovtzer A, "Thyroid cancer in children: management and outcome experience of a referral center" 135 (135): 581-584, 2006

      5 Haveman JW, "Surgical experience in children with differentiated thyroid carcinoma" 10 (10): 15-20, 2003

      6 Segal K, "Surgery of thyroid cancer in children and adolescents" 20 (20): 293-297, 1998

      7 Palmer BA, "Papillary thyroid carcinoma in children: risk factors and complications of disease recurrence" 40 (40): 1284-1288, 2005

      8 Brink JS, "Papillary thyroid cancer with pulmonary metastases in children: long-term prognosis" 128 (128): 881-886, 2000

      9 Schlumberger MJ, "Papillary and follicular thyroid carcinoma" 338 (338): 297-306, 1998

      10 Frankenthaler RA, "Lymph node metastasis from papillary-follicular thyroid carcinoma in young patients" 160 (160): 341-343, 1990

      11 Kowalski LP, "Long-term survival rates in young patients with thyroid carcinoma" 129 (129): 746-749, 2003

      12 Shah JP, "Lobectomy versus total thyroidectomy for differentiated carcinoma of the thyroid: a matchedpair analysis" 166 (166): 331-335, 1993

      13 Yang SW, "Four Cases of Papillary Thyroid Cancer in Childhood" 27 (27): 282-287, 1984

      14 Harness JK, "Differentiated thyroid carcinoma in children and adolescents" 16 (16): 547-553, 1992

      15 Grigsby PW, "Childhood and adolescent thyroid carcinoma" 95 (95): 724-729, 2002

      16 National Cancer Center, "2012 Annual report of cancer statistics in Korea" Ministry of Health & Welfare, Korea Central Cancer Registry 2014

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