Emerging evidence suggests that the microbiota‐gut‐brain axis affects a variety of complex behaviors, including social, emotional, and depressive‐like behaviors. Peyer's patches (PPs), a well‐characterized gut‐associated lymphoid tissue, are...
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https://www.riss.kr/link?id=O112928714
Ruining Xie ; Pei Jiang ; Li Lin ; Bin Yu ; Chunmei Wang ; Yanyou Pan ; Jingjing Rao ; Wei Wei ; Yi Qiao
2020년
-
0892-6638
1530-6860
SCI;SCIE;SCOPUS
학술저널
8310-8325 [※수록면이 p5 이하이면, Review, Columns, Editor's Note, Abstract 등일 경우가 있습니다.]
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
Emerging evidence suggests that the microbiota‐gut‐brain axis affects a variety of complex behaviors, including social, emotional, and depressive‐like behaviors. Peyer's patches (PPs), a well‐characterized gut‐associated lymphoid tissue, are...
Emerging evidence suggests that the microbiota‐gut‐brain axis affects a variety of complex behaviors, including social, emotional, and depressive‐like behaviors. Peyer's patches (PPs), a well‐characterized gut‐associated lymphoid tissue, are the entry site for luminal antigens and the initiation site for antigen‐specific immune responses. However, few studies have explored the composition of lymphoid tissue‐resident commensal bacteria (LRCs) in stress‐associated disorders. Male C57BL/6 mice exposed to chronic social stress were analyzed for microbiome on the interior of PPs and changes in inflammation. Susceptible mice (SUS) exhibited a composition of bacteria inside PPs that was distinct from that of control (CON) and resilient (RES) mice, including an increase in Candidatus Arthromitus (SFB) and a decrease in Lactobacillus. The CD4+CD25+Foxp3+ T cells were significantly reduced in SUS mice. Relative mRNA levels of IL‐2 were significantly reduced in SUS mice, and the mRNA levels of Bcl‐6, IFN‐γ, IL‐6, and the IgA protein levels in the ileum were significantly increased. Moreover, in the prefrontal cortex of SUS mice, IL‐6 and TNF‐α were increased, whereas IL‐10 was decreased. The correlational analyses revealed that social interaction ratio was negatively correlated with SFB and positively associated with Lactobacillus and four other candidate protective organisms. These results pointed the possibility that the changes in the LRCs induced by chronic social defeat stress were ultimately associated with the inflammation of the brain and exacerbation of depressive‐like behaviors.
Identification of histone deacetylase 8 as a novel therapeutic target for renal fibrosis