Heterozygosities of 735 microsatellite markers and backgroundlinkage disequilibrium in the Korean population

다국어 초록 (Multilingual Abstract)

Suitability of a specific population for linkage dis-equilibrium maping studies of complex traits may be assessed by investigating the background link-age disequilibrium (BLD). We are unaware of stud-ies for quantifying the degree of BLD in the Korean population, although the population may be a good candidate for mapping of complex trait genes through whole-genome association studies. It is useful to investigate the properties of genetic iso-lates in East Asia and to compare them to genetic isolates in Europe. We analyzed the extent of BLD in the Korean population using 735 microsatellite markers and compared the results with the Iceland-er population, which is one of the European ex-panded genetic isolates. The Korean population ex-hibited a level of BLD comparable with the Icelander population. The inference of population structure using the model with admixture showed that each individual has allele copies originating from K pop-ulations in equal proportions. Therefore, we believe that factors other than genetic distance, such as re-cent admixture, have not contributed to the level of BLD. Our results showed that the Korean pop-ulation, which is an expanded population with no evidence of admixture, has a BLD level comparable with the Icelander population. Therefore, the Korean population can be used for fine mapping of either complex traits or monogenic diseases.

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