RISS 검색 - 국내학술지논문 상세보기

다국어 초록 (Multilingual Abstract)

Background: The resting heart rate (HR) or HR recovery after exercise is one of the important predictors of cardiovascular disease mortality. However, few studies have addressed the ideal range of the HR. We sought to define the normal HR of healthy adults who have no evidence of cardiovascular or systemic illness, and none of the component of metabolic syndrome (MS). Methods: We analyzed a total of 20,162 asymptomatic adults, who were referred for a general health evaluation. All participants underwent careful clinical evaluation, including a detailed history, physical examination and laboratory workup. The mean HR for 30 seconds in the morning after an overnight fast was obtained. There were 7,823 subjects who were free of any component of MS. There were 935 MS patients, and 10,492 patients had ≥1 component of MS. Results: The HR was faster in women. The resting HR of healthy men was 59.9±8.2 bpm, and that of healthy women was 63.7±8.5 bpm. There was significant correlation between the HR and the age of healthy adults (r=-0.008, p<0.001). The mean resting HR was higher in the MS patients than that of their healthy counterparts (67.4±10.6 bpm vs 62.0±8.6 bpm, respectively, p=0.000). A significant gradual increase of HR was observed as the numbers of MS component increased (r=0.127, p<0.001). The systolic blood pressure, fasting blood sugar, HbA1c, triglyceride, γGTP, uric acid and CRP were significantly correlated with HR. Conclusions: We herein newly define the optimal HR in a healthy adult population. Follow-up study is needed to clarify the role of HR as a risk stratifier. (Korean J Med 72:172-180, 2007)

참고문헌 (Reference)

1 Jose AD, "The normal range and determinants of the intrinsic heart rate in man" 4 : 160-167, 1970

2 Kleiber M, "The fire of life: an introduction to animal energetics" Wiley 1961

3 Packer M, "The effect of carvediol on morbidity and mortality in chronic heart failure" 334 : 1349-1355, 1996

4 Kristal-Boneh E, "The association of resting heart rate with cardiovascular, cancer and all-cause mortality: eight year follow-up of 3527 male Israeli employees (the CORDIS study)" 21 : 116-124, 2000

5 Fillinger MP, "The association between heart rate and in-hospital mortality after coronary artery bypass graft surgery" 95 : 1483-1488, 2002

6 Schmidt-Nielsen K, "Swimming and flying. In: Scaling: Why is animal size so important?" Cambridge University Press 182-196, 1984

7 Greenland P, "Resting heart rate is a risk factor for cardiovascular and noncardiovascular mortality" 149 : 853-862, 1999

8 Staessen JA, "Randomised double‐blind comparison of placebo and active treatment for older patients with isolated systolic hypertension" 350 : 757-764, 1997

9 Ekelund LG, "Physical fitness as a predictor of cardiovascular mortality in asymptomatic North American men" 319 : 1379-1384, 1988

10 Grassi G, "Neuroadrenergic and reflex abnormalities in patients with metabolic syndrome" 48 : 1359-1365, 2005