1 Zheng, S., "Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020 : Retrospective cohort study" 369 : m1443-, 2020
2 Zhang, X., "Viral and host factors related to the clinical outcome of COVID-19" 583 : 437-440, 2020
3 Kasowski, M., "Variation in transcription factor binding among humans" 328 : 232-235, 2010
4 Hung, I. F. N., "Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19 : an open-label, randomised, phase 2 trial" 395 : 1695-1704, 2020
5 Simon C. Biddie, "Transcription Factor AP1 Potentiates Chromatin Accessibility and Glucocorticoid Receptor Binding" Elsevier BV 43 (43): 145-155, 2011
6 Jesse R. Dixon, "Topological domains in mammalian genomes identified by analysis of chromatin interactions" Springer Science and Business Media LLC 485 (485): 376-380, 2012
7 Carlos Salama, "Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia" Massachusetts Medical Society 384 (384): 20-30, 2021
8 Parascandola, M., "Tobacco and the lung cancer epidemic in China" 8 : S21-S30, 2019
9 David A. Dorward, "Tissue-Specific Immunopathology in Fatal COVID-19" American Thoracic Society 203 (203): 192-201, 2021
10 Pan, F., "Time course of lung changes on chest CT during recovery From 2019 novel coronavirus(COVID-19)pneumonia" 295 : 715-721, 2020
11 Thavarajah, T., "The plasma peptides of sepsis" 17 : 26-, 2020
12 Karczewski, K. J., "The mutational constraint spectrum quantified from variation in 141, 456 humans" 581 : 434-443, 2020
13 Thurman, R. E., "The accessible chromatin landscape of the human genome" 489 : 75-82, 2012
14 Vaarala, M. H., "The TMPRSS2gene encoding transmembrane serine protease is overexpressed in a majority of prostate cancer patients : detection of mutated TMPRSS2 form in a case of aggressive disease" 94 : 705-710, 2001
15 GTEx Consortium., "The Genotype-Tissue Expression(GTEx)pilot analysis : multitissue gene regulation in humans" 348 : 648-660, 2015
16 Chen, L., "The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2" 116 : 1097-1100, 2020
17 To, K. K. W., "Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV2 : an observational cohort study" 20 : 565-574, 2020
18 Zang, R., "TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes" 5 : eabc3582-, 2020
19 Maurano, M. T., "Systematic localization of common disease-associated variation in regulatory DNA" 337 : 1190-1195, 2012
20 Melnikov, A., "Systematic dissection and optimization of inducible enhancers in human cells using a massively parallel reporter assay" 30 : 271-277, 2012
21 Zou, X., "Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection" 14 : 185-192, 2020
22 Zhao, Y., "Single-cell RNA expression profiling of ACE2, the receptor of SARS-CoV-2" 202 : 756-759, 2020
23 Wang, A., "Single cell multiomic profiling of human lung reveals cell type-specific and age-dynamic control of SARS-CoV2 host genes" 9 : e62522-, 2020
24 Qi, F., "Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses" 526 : 135-140, 2020
25 Baratchian, M., "Sex, androgens and regulation of pulmonary AR, TMPRSS2 and ACE2"
26 Liu, J., "Sex differences in renal angiotensin converting enzyme 2(ACE2)activity are 17β-oestradiol-dependent and sex chromosome-independent" 1 : 6-, 2010
27 Giacomelli, A., "Self-reported olfactory and taste disorders in SARS-CoV-2 patients : a cross-sectional study" 71 : 889-890, 2020
28 Pujadas, E., "SARS-CoV-2 viral load predicts COVID-19 mortality" 8 : e70-, 2020
29 Fajnzylber, J., "SARS-CoV-2 viral load is associated with increased disease severity and mortality" 11 : 1-9, 2020
30 Ziegler, C. G. K., "SARS-CoV-2 receptor ACE2 Is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues" 181 : 1016-1035, 2020
31 Lukassen, S., "SARS-CoV-2 receptor ACE 2 and TMPRSS 2 are primarily expressed in bronchial transient secretory cells" 39 : e10511-, 2020
32 Sungnak, W., "SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes" 26 : 681-687, 2020
33 Wang, J., "Respiratory influenza virus infection induces intestinal immune injury via microbiotamediated Th17 cell-dependent inflammation" 211 : 2397-2410, 2014
34 WHO Solidarity Trial Consortium, Pan, H., "Repurposed antiviral drugs for covid-19—interim WHO solidarity trial results" 384 : 497-511, 2020
35 Zhao, J., "Relationship between the ABO Blood Group and the COVID-19susceptibility" ciaa1150-, 2020
36 Tomlins, S. A., "Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer" 310 : 644-648, 2005
37 Wan, Y., "Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS coronavirus" 94 : e00127-20, 2020
38 Bukowska, A., "Protective regulation of the ACE2/ACE gene expression by estrogen in human atrial tissue from elderly men" 242 : 1412-1423, 2017
39 Lin, B., "Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2" 59 : 4180-4184, 1999
40 Szabo, Q., "Principles of genome folding into topologically associating domains" 5 : eaaw1668-, 2019
41 Xu, Z., "Pathological findings of COVID-19 associated with acute respiratory distress syndrome" 8 : 420-422, 2020
42 Yang, J., "Pathological Ace2-to-Ace enzyme switch in the stressed heart is transcriptionally controlled by the endothelial Brg1-FoxM1 complex" 113 : E5628-E5635, 2016
43 최윤영, "Oligoadenylate synthase-like (OASL) proteins: dual functions and associations with diseases" 생화학분자생물학회 47 : 1-8, 2015
44 Chen, L., "Ocular manifestations of a hospitalised patient with confirmed 2019 novel coronavirus disease" 104 : 748-751, 2020
45 Bunyavanich, S., "Nasal gene expression of angiotensinconverting enzyme 2 in children and adults" 363 : 2427-2429, 2020
46 Puelles, V. G., "Multiorgan and renal tropism of SARS-CoV-2" 383 : 590-592, 2020
47 Yang, X. H., "Mice transgenic for human angiotensin-converting enzyme 2 provide a model for SARS coronavirus infection" 57 : 450-459, 2007
48 Lucas, C., "Longitudinal analyses reveal immunological misfiring in severe COVID-19" 584 : 463-469, 2020
49 Tukiainen, T., "Landscape of X chromosome inactivation across human tissues" 550 : 244-248, 2017
50 REMAP-CAP Investigators, "Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19" Massachusetts Medical Society 384 (384): 1491-1502, 2021
51 Onabajo, O. O., "Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor" 52 : 1283-1293, 2020
52 Leung, D., "Integrative analysis of haplotype-resolved epigenomes across human tissues" 518 : 350-354, 2015
53 Muus, C., "Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells"
54 Chen, J., "Individual variation of the SARS-CoV-2 receptor ACE2 gene expression and regulation" 19 : e13168-, 2020
55 Zhang, Q., "Inborn errors of type I IFN immunity in patients with lifethreatening COVID-19" 370 : eabd4570-, 2020
56 Hadjadj, J., "Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients" 369 : 718-724, 2020
57 Breidenbach, J. D., "Impact of comorbidities on SARS-CoV-2 viral entryrelated genes" 10 : 1-11, 2020
58 Blanco-Melo, D., "Imbalanced host response to SARS-CoV-2 drives development of COVID-19" 181 : 1036-1045, 2020
59 Cheng, Z., "Identification of TMPRSS2 as a susceptibility gene for severe 2009 pandemic A(H1N1)influenza and A(H7N9)influenza" 212 : 1214-1221, 2015
60 Hurst, S. M., "IL-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation" 14 : 705-714, 2001
61 Shepardson, K. M., "IFNAR2 is required for anti-influenza immunity and alters susceptibility to post-influenza bacterial superinfections" 9 : 2589-, 2018
62 Gadotti, A. C., "IFN-γ is an independent risk factor associated with mortality in patients with moderate and severe COVID-19 infection" 289 : 198171-, 2020
63 Lee, N., "IFITM3, TLR3, and CD55 Gene SNPs and cumulative genetic risks for severe outcomes in chinese patients With H7N9/H1N1pdm09 influenza" 216 : 97-104, 2017
64 Vuille-Dit-Bille, R. N., "Human intestine luminal ACE2 and amino acid transporter expression increased by ACE-inhibitors" 47 : 693-670, 2015
65 Kreins, A. Y., "Human TYK2 deficiency : mycobacterial and viral infections without hyper-IgE syndrome" 212 : 1641-1662, 2015
66 Kumasaka, N., "High-resolution genetic mapping of putative causal interactions between regions of open chromatin" 51 : 128-137, 2019
67 Kerpedjiev, P., "HiGlass : web-based visual exploration and analysis of genome interaction maps" 19 : 125-, 2018
68 Ortiz, M. E., "Heterogeneous expression of the SARS-Coronavirus-2receptor ACE2 in the human respiratory tract" 60 : 102976-, 2020
69 Zhou, Z., "Heightened innate immune responses in the respiratory tract of COVID-19 patients" 27 : 883-890, 2020
70 Alexis J. Combes, "Global absence and targeting of protective immune states in severe COVID-19" Springer Science and Business Media LLC 591 (591): 124-130, 2021
71 Ellinghaus, D., "Genomewide Association Study of Severe Covid-19 with Respiratory Failure" 383 : 1522-1534, 2020
72 Fingerlin, T. E., "Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis" 45 : 613-620, 2013
73 Li, B., "Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection" 11 : 164-, 2020
74 Bovijn, J., "Genetic variants mimicking therapeutic inhibition of IL-6 receptor signaling and risk of COVID-19" 2 : e658-e659, 2020
75 Erola Pairo-Castineira, "Genetic mechanisms of critical illness in COVID-19" Springer Science and Business Media LLC 591 (591): 92-98, 2021
76 Jin, J. M., "Gender differences in patients with COVID-19 : focus on severity and mortality" 8 : 152-, 2020
77 Tu, X., "Functional polymorphisms of the CCL2 and MBL genes cumulatively increase susceptibility to severe acute respiratory syndrome coronavirus infection" 71 : 101-109, 2015
78 Li, M. Y., "Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues" 9 : 45-, 2020
79 Ma, D., "Expression of SARS-CoV-2 receptor ACE2 and TMPRSS2 in human primary conjunctival and pterygium cell lines and in mouse cornea" 34 : 1212-1219, 2020
80 Cummings, M. J., "Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City : a prospective cohort study" 395 : 1763-1770, 2020
81 Dong, Y., "Epidemiology of COVID-19 among children in China" 145 : 20200702-, 2020
82 Varga, Z., "Endothelial cell infection and endotheliitis in COVID-19" 395 : 1417-1418, 2020
83 Angus, D. C., "Effect of hydrocortisone on mortality and organ support in patients with severe COVID-19 : The REMAP-CAP COVID-19 corticosteroid domain randomized clinical" 324 : 1317-1329, 2020
84 Baena, E., "ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients" 27 : 683-698, 2013
85 RECOVERY Collaborative Group, "Dexamethasone in hospitalized patients with covid-19—preliminary report" 384 : 693-704, 2020
86 Chen, C. H., "Determinants of transcription factor regulatory range" 11 : 2472-, 2020
87 Hanako Ishida, "Cryo-EM structures of Toll-like receptors in complex with UNC93B1" Springer Science and Business Media LLC 28 (28): 173-180, 2021
88 Schreiber, J., "Completing the ENCODE3 compendium yields accurate imputations across a variety of assays and human biosamples" 21 : 82-, 2020
89 Huang, C., "Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China" 39 : 497-506, 2020
90 Zhou, F., "Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China : a retrospective cohort study" 295 : 1054-1062, 2020
91 Guan, W., "Clinical characteristics of coronavirus disease 2019 in China" 382 : 1708-1720, 2020
92 Smith, J. C., "Cigarette smoke exposure and inflammatory signaling increase the expression of the SARS-CoV-2 receptor ACE2 in the respiratory tract" 53 : 514-529, 2020
93 Wein, A. N., "CXCR6 regulates localization of tissue-resident memory CD8T cells to the airways" 216 : 2748-2762, 2019
94 Grasselli, G., "Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy Region, Italy" 323 : 1574-1581, 2020
95 Argyropoulos, K. V., "Association of initial viral load in severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)patients with outcome and symptoms" 190 : 1881-1887, 2020
96 Li, G., "Assessing ACE2 expression patterns in lung tissues in the pathogenesis of COVID-19" 112 : 102463-, 2020
97 Chen, Y., "Asians do not exhibit elevated expression or unique genetic polymorphisms for ACE2, the cell-entry receptor of SARSCoV-2"
98 Imai, Y., "Angiotensin-converting enzyme 2 protects from severe acute lung failure" 436 : 112-116, 2005
99 Pierre-Jean Lamy, "Androgenic hormones and the excess male mortality observed in COVID-19 patients: new convergent data" Springer Science and Business Media LLC 39 (39): 3121-3123, 2021
100 Wambier, C. G., "Androgenetic alopecia present in the majority of patients hospitalized with COVID-19 : The"Gabrin sign"" 83 : 680-682, 2020
101 Schuler, B. A., "Age-determined expression of priming protease TMPRSS2and localization of SARS-CoV-2 in lung epithelium" 131 : e140766-, 2020
102 Grobe, J. L., "ACE2 overexpression inhibits hypoxia-induced collagen production by cardiac fibroblasts" 113 : 357-364, 2007
103 Asselta, R., "ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19severity in Italy" 12 : 10087-10098, 2020
104 Leung, J. M., "ACE-2 expression in the small airway epithelia of smokers and COPD patients : implications for COVID-19" 55 : 2000688-, 2020
105 Fadason, T., "A transcription regulatory network within the ACE2locus may promote a pro-viral environment for SARS-CoV-2 by modulating expression of host factors"
106 Hoffmann, M., "A multibasic cleavage site in the spike protein of SARS-CoV-2 Is essential for infection of human lung cells" 78 : 779-784, 2020
107 Travaglini, K. J., "A molecular cell atlas of the human lung from single-cell RNA sequencing" 587 : 619-625, 2020
108 Schmitt, A. D., "A compendium of chromatin contact maps reveals spatially active regions in the human genome" 17 : 2042-2059, 2016
109 Rao, S. S. P., "A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping" 159 : 1665-1680, 2014