마이크로 CT를 이용한 BALB/C(흰쥐) 간문맥의 미세혈관 조영 영상

국문 초록 (Abstract)

고해상도 엑스선 영상장치인 마이크로 CT를 이용, 흰쥐 간의 전체적인 문맥상과 각 간엽(lobe)의 미세혈관구조를 관찰하여 4개 분절 간엽의 구조를 영상화 하였고, 단축면상의 데이터를 3D영상으로 재구성한 미세혈관 구조의 입체적인 영상을 획득할 수 있는 마이크로 CT에 대한 유용성을 알아보고자 하였다.
5마리의 간 중에서 손상이 가장 적은 1개의 간을 4 개의 분절 간엽으로 각각 절단하여 문맥의 미세구조를 이차원으로 구성하였으며, MIP기법을 이용하여 간 문맥 전체 미세혈관의 3D영상을 얻었으며, 각 간엽의 미세혈관은 6분지까지 관찰할 수 있었다. 6 분지까지의 크기를 측정한 결과 평균치는 1 branch : 0.51 ㎜ ±0.08, 2 branch : 0.32 ㎜ ± 0.12, 3 branch : 0.23 ㎜ ± 0.11, 4 branch : 0.19 ㎜ ± 0.08, 5 branch : 0.13 ㎜ ± 0.06, 6 branch : 70.5 ㎛ ± 14.1 로 측정되었다.
본 연구의 실험 결과에서 획득한 3차원의 입체 영상과 미세혈관 구조의 발견은 향후 고해상력의 영상을 얻을 수 있는 마이크로 CT가 많이 이용될 수 있을 것으로 기대된다.

다국어 초록 (Multilingual Abstract)

The study focuses on the value of Micro CT, a high resolution X-ray imaging device, by using it on rats to observe the overall portal vein image of the liver and the microvasculature of each lobes, visualize the 4 segmental lobes and acquire 3D image of the microvasculature through the reconstruction of sectional image data. Less of the damage to liver of the 5 mice, the device was able to separate the liver into 4 segmental lobes and displayed the 4 portal vein microvasculature in 2D. By using the 3D MIP technique, observation of the whole portal vein system microvasculature in 3D image was made possible along with each of the portal vein segment's branches until the 6th branch. Measured the size of 6branch, the average was measured at 1branch : 0.51 ㎜ ± 0.08, 2 branch : 0.32 ㎜ ± 0.12, 3 branch : 0.23 ㎜ ± 0.11, 4 branch : 0.19 ㎜ ± 0.08, 5 branch : 0.13 ㎜ ± 0.06, 6 branch : 70.5 ㎛ ± 14.1.
The 3D image and the images of the microvasculatures in the result of study proved that the Micro-CT can be considered many useful device in obtaining high resolution images.

목차 (Table of Contents)

• 요약
• Abstract
• Ⅰ. 서론
• Ⅱ. 실험대상 및 방법
• Ⅲ. 결과 및 고찰
• Ⅳ. 결론
• 참고문헌
• 저자소개

참고문헌 (Reference)

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