ACE Inhibition of the Aqueous Extracts from Fruit Bodies of Ganoderma Iucidum

다국어 초록 (Multilingual Abstract)

To elucidate the chemical properties of antihypertensive components in the crude drug, Ganoderma Iucidum. we have studied the inhibitory effect of the aqueous extracts from the fruit bodies of G Iucidum on angiotensin 1 converting enzyme (ACE) activity. The aqueous extracts moderately inhibited the activity of ACE with respect to Hippuryl-histidyl-leucine(HHL) substrate. G Lucidium obtained from Hwasung showed higher ACE inhibitory activity in terms of higher IC50 values. The kinetics of ACE inhibition by the aqueous extracts from the crude drugs was plotted according to Lineweaver and Burk. The aqueous extracts inhibited the ACE activity. Mannitol and arabitol acting as moderate ACE inhibitors were found in the aqueous extracts. However, these polyhydric alcohols inhibited the ACE activity to a lesser extent compared with the aqueous extracts, suggesting that another type of more potent inhibitors exist in the aqueous extract of the crude drug.