Altered expression of placental aging markers is associated with pathogenesis of preeclampsia = Altered expression of placental aging markers is associated with pathogenesis of preeclampsia

다국어 초록 (Multilingual Abstract)

Objective: Previous studies suggest, senescence of trophoblast is thought to be associated to the development of preeclampsia (PE). Therefore, this study aimed to confirm whether the expression of placental aging-related markers reveal a difference in a rat model of preeclampsia induced by reduced uterine perfusion pressure (RUPP).
Methods: To confirm PE of RUPP rat models, the changes in blood pressure, urine protein, serum level of PE marker (VEGF, s-Flt) and fetal and placental weight were measured in rat model with RUPP. We also measured the differential expressions of placental aging-related markers (calprotectin and caveolin-1) in the placenta and serum of PE rat model by real-time PCR, ELISA, and immunohistochemistry.
Results: 1) The tail blood pressure, urine protein, stillbirth rate, fetal and placental wight measured in the PE rat model were statistically changed compare to the Sham group(dpc18.5). 2) The expressions of calprotectin in the placenta and serum of RUPP models were increased. But, the level of caveolin-1 was decreased.
Conclusion: These results suggest that altered expression of placental aging-related markers such as calprotectin and caveolin-1 might be involved in pathogenesis of PE. And additional experiment using human samples complicated of PE are warranted.