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      KCI등재 SCIE SCOPUS

      The Inhibitory Effect of Rosiglitazone on Agonist-Induced or Spontaneous Regulation of Contractility

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      https://www.riss.kr/link?id=A104665688

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      다국어 초록 (Multilingual Abstract)

      The present study was undertaken to determine whether rosiglitazone treatment influences on the agonist-induced or spontaneous regulation of vascular smooth muscle contraction and, if so, to investigate the related mechanism. Stimulants were directly ...

      The present study was undertaken to determine whether rosiglitazone treatment influences on the agonist-induced or spontaneous regulation of vascular smooth muscle contraction and, if so, to investigate the related mechanism. Stimulants were directly added without any preanesthetic stress or spontaneous vasoconstriction was induced by preanesthetic physical stress where rat aortic ring preparations isolated from rat exposed to preanesthetic stress such as pinch or prick for 30 min were mounted in organ baths and then exposed to contractile agents.
      Previously and subchronically ingested rosiglitazone decreased Rho-kinase activating agonistinduced contraction but not depolarization- or α adrenergic agonist-induced contraction. Moreover, preanesthetic stress induced the stress-induced spontaneous contraction and previously and subchronically ingested rosiglitazone abolished the stress-induced spontaneous contraction.
      In conclusion, this study provides the evidence and possible related mechanism concerning the vasorelaxing effect of an antidiabetic rosiglitazone as an antihypertensive on the agonist-induced contraction or stress-induced spontaneous vasoconstriction in rat aortic rings regardless of endothelial function.

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      참고문헌 (Reference)

      1 "α1-Adrenergic signaling mechanisms in contraction of resistance arteries" 150 : 91-139, 2003

      2 "Thromboxane A 2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca 2+ entry and Ca 2+ sensitization"

      3 "Thiazolidinedione derivatives in type 2 diabetes mellitus" 64 : 166-174, 2006

      4 "The thiazolidinedione rosiglitazone (BRL-49653) lowers blood pressure and protects against impairment of endothelial function in Zucker faty rats" 48 : 1448-1453, 1999

      5 "Stress, anxiety and cardiovascular disease: an interdisciplinary approach" 15 : 21-31, 2004

      6 "Signal transduction and regulation in smooth muscle. Nature" 231-236, 1994

      7 "Roles for G(12)/ G(13) in agonist-induced vascular smooth muscle cell contraction" 87 : 221-227, 2000

      8 "Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho" 15 : 2208-2216, 1996

      9 "Protein-mediated inhibition of myosin light-chain phosphatase in vascular smooth muscle. Proc. Natl. Acad. Sci. U.S.A." 9307-9310, 1991

      10 "Pioglitazone, a PPARgamma agonist, restores endothelial function in aorta of streptozotocin-induced diabetic rats" 66 : 150-161, 2005

      1 "α1-Adrenergic signaling mechanisms in contraction of resistance arteries" 150 : 91-139, 2003

      2 "Thromboxane A 2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca 2+ entry and Ca 2+ sensitization"

      3 "Thiazolidinedione derivatives in type 2 diabetes mellitus" 64 : 166-174, 2006

      4 "The thiazolidinedione rosiglitazone (BRL-49653) lowers blood pressure and protects against impairment of endothelial function in Zucker faty rats" 48 : 1448-1453, 1999

      5 "Stress, anxiety and cardiovascular disease: an interdisciplinary approach" 15 : 21-31, 2004

      6 "Signal transduction and regulation in smooth muscle. Nature" 231-236, 1994

      7 "Roles for G(12)/ G(13) in agonist-induced vascular smooth muscle cell contraction" 87 : 221-227, 2000

      8 "Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho" 15 : 2208-2216, 1996

      9 "Protein-mediated inhibition of myosin light-chain phosphatase in vascular smooth muscle. Proc. Natl. Acad. Sci. U.S.A." 9307-9310, 1991

      10 "Pioglitazone, a PPARgamma agonist, restores endothelial function in aorta of streptozotocin-induced diabetic rats" 66 : 150-161, 2005

      11 "Peroxisome proliferator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells" 83 : 1097-1103, 1998

      12 "PPARgamma activation in human endothelial cells increases plasminogen activator inhibitor type-1 expresion: PPAR- gamma as a potential mediator in vascular disease" 19 : 546-551, 1999

      13 "From pharmacomechanical coupling to G- proteins and myosin phosphatase" 164 : 437-448, 1998

      14 "Fluid retention and vascular effects of rosiglitazone in obese, insulin-resistant, nondiabetic subjects" 29 : 581-587, 2006

      15 "Cardiovascular, hormone, and lipid responses to stress induced by virtual crane handling" 18 : 357-365, 2005

      16 "Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension" 389 : 990-994, 1997

      17 "Ca 2+-dependent activation of Rho and Rho-kinase in membrane depolarization-induced and receptor stimulation-induced vascular smooth muscle con- traction" 93 : 548-556, 2003

      18 "Activation of MAP kinases and phosphorylation of caldesmon in canine colonic smooth muscle" 495 : 597-609, 1996

      19 "A role for Rho kinase in vascular contraction evoked by sodium fluoride" 343 : 27-33, 2006

      20 "A novel serine/ threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes" 270 : 29051-29054, 1995

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      유사연구자 (20) 활용도상위20명

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2020-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2010-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2008-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2006-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2004-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2001-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      1998-07-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 1.96 0.2 1.44
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      1.07 0.87 0.439 0.05
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