글리세린, 히알루론산, 실리콘 오일이 피부의 보습 및 경피수분손실량에 미치는 효과 = The Effect of Glycerin, Hyaluronic Acid and Silicone Oil on the Hydration, Moisturization and Transepidermal Water Loss in Human Skin

다국어 초록 (Multilingual Abstract)

In the cosmetic industry, various moisturizing ingredients have been developed to improve skin dryness getting worse by extrinsic and intrinsic factors. However, there are no well defined studies about the actual hydrating ability and holding time of the moisturizing factors. In this study, we compared and investigated the efficacy of glycerin,hyaluronic acid and silicone oil (dimethicone), which are generally and most widely used as moisturizing ingredients in the cosmetic industry to improve skin hydration and transepidermal water loss (TEWL). Comparing skin moisturizing abilities before application and 30 minutes and 6 hours after application of six creams with or without glycerin,hyaluronic acid and/or silicone oil, the cream including both glycerin and silicone oil showed the highest moisturizing value and the longest holding time of hydration. The second on the result was the cream containing both hyaluronic acid and silicone oil, followed by the glycerin cream, hyaluronic acid cream and silicone oil cream. Comparing TEWL before application and 30 minutes and 6 hours after application of six creams with or without glycerin, hyaluronic acid and/or silicone oil, the cream including both glycerin and silicone oil showed the most decreased value of TEWL and the longest holding time. The second on the result was the cream with both hyaluronic acid and silicone oil, followed by the silicone oil cream, the glycerin cream and the hyaluronic acid cream. Although glycerin, hyaluronic acid and silicone oil affect increasing skin hydration and decreasing TEWL, our data showed that the product containing not only silicone but also moisture factors such as glycerin and hyaluronic acid is more effective rather than applying the product with silicone oil only. As a result, the product containing glycerin with hyaluronic acid and/or silicone oil showed the superior abilities to increase skin hydration and decrease TEWL. Therefore, we suggest that our results aid in the development of various moisturizers as the basic standards and more study should be conducted to investigate the efficacy of various moisturizers on human skin hydration and TEWL.

참고문헌 (Reference)

1 오유경, "화장품 보습제의 활용방안에 관한 고찰" 11 : 137-150, 2009

2 김상현, "피부장벽손상이 TEWL에 미치는 영향과 호호바 오일의 피부장벽복구 역할에 대한 연구" 대한피부미용학회 3 (3): 189-200, 2005

3 하병조, "키토산 올리고당의 보습성과 생리활성에 관한 연구" 31 : 6-22, 1999

4 심정묘, "천연 성분으로 만든 수분크림이 보습과 지속력에 미치는 영향" 대한피부미용학회 9 (9): 1-7, 2011

5 박민숙, "여대생의 여드름피부와 예민피부의 유·수분 및 pH, 탄력도 비교연구" 성신여자대학교 문화산업대학원 2009

6 한상철, "실리콘 다중유제 (W/Si/W)를 이용한 화장용 티슈의 개발 및 평가" 충남대학교 대학원 2007

7 강호정, "수종의 보습기제의 피부보습효과에 관한 연구" 34 : 869-874, 1996

8 한경준, "보습제의 기제에 따른 피부보습효과에 관한 연구" 29 : 8-17, 1991

9 장혜진, "보습제 원료의 세포자극성 및 피부보습에 미치는 정도에 관한 연구" 대한피부미용학회 3 (3): 143-152, 2005

10 이민희, "목초액을 이용한 화장품의 피부보습 효과에 관한 연구" 건양대학교 대학원 2009

11 차미나, "Sodium hyaluronate와 Liposome hyaluronate의 보습 효능 비교" 건국대학교 산업대학원 2010

12 Alberts B, "Molecular Biology of the Cell" Garland Publishing Inc 200-201, 1994

13 배덕환, "Hydrogenated 레시친으로 안정화된 Silicone Nanoemulsion" 11 : 522-528, 2000

14 서영수, "Hyaluronic Acid의 특성과 응용" 12 : 484-488, 1988

15 Rim JH, "Electrical measurement of moisturizing effect on skin hydration and barrier function in psoriasis patients" 30 : 409-413, 2005

16 권지영, "EDC로 가교된 Hyaluronic acid-lactide막의 제조 및 특성" 한남대학교 대학원 2006

17 김석민, "Cosmetic Dermatology" 정담미디어 51-, 2004

18 Batt MD, "Changes in the physical properties of the stratum corneum following treatment with glycerol" 39 : 367-381, 1988

19 Jacobi OK, "About the mecanism of moisture regulation in the horny layer of the skin" 31 : 22-24, 1959