4’-selenonucleosides are third-generation of nucleosides which has been developed for anti-viral agent. So far seven 4’-selenonucleoside's structures are determined by x-ray crystallography. Seven crystal structures are compared and characterized ...
4’-selenonucleosides are third-generation of nucleosides which has been developed for anti-viral agent. So far seven 4’-selenonucleoside's structures are determined by x-ray crystallography. Seven crystal structures are compared and characterized for the detailed furanose ring structure and environment. Most 4’-seleno nucleosides shows south conformation on the furanose ring puckering because of the electron-rich selenium atom. However N7 regio-isomer of selenoadenosine which is substituted by chlorine at N6 position, has a north conformation due to the steric effect of bulky chlorine atom. Also the x-ray crystal structure of 4’-selenoadenosine revealed an unusual mixture of north and south conformations by DNA-like base paring and base stacking. It is expected that this structural investigation of 4’-selenonucleosides is useful for the design of therapeutically effective antiviral agents.